In this study, researchers assessed vitamin D3 levels in adolescents, finding a suboptimal average of 22.00 ng/ml, and demonstrated that supplementing with 1000 IU/day of vitamin D3 significantly raised levels and improved physical and mental potential over two months.
1 citations
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August 2012 in “Pediatrics in review” This paper reviews various vitamin deficiencies, including vitamin D, and highlights their potential health impacts. It does not report new research findings but discusses current recommendations and risks associated with these deficiencies.
September 2005 in “CRC Press eBooks” This study reports that the epidermis is both a source and target for vitamin D3's active form, influencing skin and hair follicle differentiation through a calcium-mediated pathway.
39 citations
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January 1997 in “Pharmacology & toxicology” This study found that human keratinocytes' sensitivity and response to vitamin D3 analogues vary based on cell density, serum availability, and calcium concentration.
2 citations
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January 2025 in “Brazilian Journal of Medical and Biological Research” This study demonstrated that VD3 significantly enhanced the proliferation and differentiation of epidermal stem cells in a murine skin defect model, leading to improved wound healing, potentially through activation of the PI3K signaling pathway.
Vitamin D is crucial for skin health and managing skin diseases.
12 citations
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September 1997 in “PubMed” This review explores how vitamin D3 analogs could target various skin processes and diseases, potentially offering selective and effective treatments beyond psoriasis, but reports no new clinical findings.
June 2024 in “The Journal of Nutritional Biochemistry” This study found that 1,25-dihydroxyvitamin D3 promotes hair growth and regeneration in mice by prolonging the anagen phase and counteracting DHT's inhibitory effects, suggesting its potential therapeutic role for androgenetic alopecia.
1 citations
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March 2015 in “PubMed” This review discusses the role of vitamin D and its receptor in maintaining skin and hair follicle health, but it reports no new clinical findings.
20 citations
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November 2008 This chapter discusses the production, metabolism, and mechanism of action of Vitamin D, including its role in calcium and phosphate metabolism and its function in the epidermis and hair follicles, without presenting new research findings.
98 citations
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February 2010 in “Dermatology Online Journal” This article outlines the potential for upregulating the vitamin D receptor in treating hair disorders, emphasizing the need for further studies to evaluate vitamin D's role in the hair cycle.
70 citations
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November 1984 in “Cell & tissue research/Cell and tissue research” Vitamin D3 affects cell differentiation in specific skin areas.
158 citations
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August 2011 in “Reviews in endocrine and metabolic disorders” This review examines the functions of vitamin D and its receptor in skin and explores how these are regulated, reporting no new clinical results.
40 citations
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October 2002 in “Endocrinology” In this study, synthetic vitamin D3 analogs stimulated hair growth and formation of normal hair follicles in nude mice, unlike the natural form 1,25 dihydroxyvitamin D3.
185 citations
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June 2011 in “Molecular and cellular endocrinology” This review discusses the regulation and function of vitamin D and its receptor in skin cells, highlighting their roles in processes such as proliferation inhibition, differentiation, and innate immunity, but reports no new results.
14 citations
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November 2005 in “Life sciences” This study indicates that vitamin D3 administration may protect rat hair follicles from radiation-induced damage, as evidenced by maintained follicle numbers and increased Vitamin D receptor activity in treated skin.
December 2021 in “Trichology and cosmetology:” This study demonstrated that a daily oral supplement of 1000 mg Kera-Diet® improved hair and nail conditions in women experiencing acute telogen effluvium and brittle nail syndrome over three months.
7 citations
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July 2021 in “PubMed” This review assesses the role of vitamins A, B, C, and D in treating dermatologic conditions and highlights promising applications, although further research is required to confirm their efficacy.
This review examines the role of vitamin D and its receptor in skin functions, exploring mechanisms regulating proliferation, differentiation, immunity, and tumor suppression, without reporting new research findings.
October 1990 in “Pediatric Research” This case report details a severe instance of VDR-II where intravenous calcium infusions, administered nightly, successfully improved clinical, radiological, and biochemical signs of rickets without alopecia despite ineffective calcitriol therapy.
3 citations
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July 1992 in “Clinics in Dermatology” This article reviews the role of vitamin D and its metabolites in regulating calcium homeostasis and highlights their effects on the intestine, kidney, bone, and parathyroid gland, without reporting new clinical results.
13 citations
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July 2007 in “Pediatric dermatology” In this case report, an ointment containing 1.24R-dihydroxyvitamin D3 was effective for treating follicular keratosis of the chin but did not provide lasting benefits after treatment ended.
32 citations
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July 2012 in “Stem Cells Translational Medicine” In this study, VD(3) pretreatment increased hair follicle formation in a rat model by promoting dermal papilla cell differentiation, suggesting potential for hair regeneration therapy.
188 citations
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January 2003 in “Recent results in cancer research/Recent Results in Cancer Research” This review explores the biological functions of vitamin D, highlighting how deficiency may increase the risk of various diseases, but reports no new clinical results.
88 citations
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October 1983 in “The Journal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism” In this study, distinct clinical responses and long-term resistances were observed in two pediatric patients with vitamin D-dependency type II, associated with abnormalities in their skin fibroblast interactions with 1,25-(OH)2D3.
2 citations
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February 1990 in “PubMed” In this study, 1,25-dihydroxyvitamin D3 inhibited growth and promoted differentiation in normal hair follicle cells but did not affect cells from a patient with vitamin D-dependent rickets type II, assisting in potential rapid diagnosis of the condition.
23 citations
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October 2009 in “Gastroenterology” This article reviews the multifaceted roles of vitamin D beyond bone health and notes its potential involvement in reducing risks of certain cancers and autoimmune diseases, but it presents no new clinical results.
36 citations
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February 2007 in “Journal of biological chemistry/The Journal of biological chemistry” This study found that vitamin D receptor activation in primary keratinocytes can occur independently of the 1,25-dihydroxyvitamin D3 ligand, likely through interaction with retinoid X receptors.
January 2012 in “Human health handbooks” This review examines the various functions of vitamin D and its receptor in regulating skin processes, highlighting their role in cell differentiation, immunity, and tumor suppression, but reports no new clinical results.
2 citations
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January 2008 in “Cuadernos de Psiquiatría comunitaria” This review examines how vitamin D and its receptor regulate various skin functions, such as cell differentiation and immunity, and explores the mechanisms involved, without reporting new clinical results.