TLDR Vitamin D and its receptor help regulate skin functions like cell growth, immunity, and hair cycle.
This document reviewed the role of keratinocytes in the skin as a primary source of vitamin D and their ability to metabolize it into active forms, particularly 1,25(OH)(2)D, which interacts with the vitamin D receptor (VDR). It discussed how vitamin D and VDR regulate several skin functions, including inhibiting proliferation, stimulating differentiation, promoting innate immunity, regulating the hair follicle cycle, and suppressing tumor formation. The regulation of these functions involved various coregulator complexes, such as the DRIP complex, SRC family, hairless (Hr), and β-catenin, each contributing differently to VDR-regulated activities. The review aimed to explore the mechanisms by which vitamin D and its receptor influence skin functions.
48 citations
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January 2015 in “Indian Journal of Dermatology, Venereology and Leprology” Vitamin D is important for skin health and can help treat psoriasis, atopic dermatitis, and vitiligo.
185 citations
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June 2011 in “Molecular and cellular endocrinology” Skin cells produce and activate vitamin D, which regulates skin functions and supports hair growth.
158 citations
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August 2011 in “Reviews in endocrine and metabolic disorders” Vitamin D and its receptor regulate skin functions like cell growth, immunity, hair cycle, and tumor prevention.
15 citations
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March 2000 in “The journal of investigative dermatology/Journal of investigative dermatology” As skin cells mature, vitamin D receptor levels decrease while retinoid X receptor α levels increase.
119 citations
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July 2016 in “Annals of the New York Academy of Sciences” Vitamin D has potential benefits for cancer prevention, heart health, diabetes, obesity, muscle function, skin health, and immune function, but clinical results are mixed and more research is needed.
Vitamin D is crucial for skin health and managing skin diseases.
