Art Therapy

    January 2008 in “ Cuadernos de Psiquiatría comunitaria ”
    José Guimón Ugartechea
    TLDR Vitamin D and its receptor help regulate skin functions like cell growth, immunity, and hair cycle.
    This document reviewed the role of keratinocytes in the skin as a primary source of vitamin D and their ability to metabolize it into active forms, particularly 1,25(OH)(2)D, which interacts with the vitamin D receptor (VDR). It discussed how vitamin D and VDR regulate several skin functions, including inhibiting proliferation, stimulating differentiation, promoting innate immunity, regulating the hair follicle cycle, and suppressing tumor formation. The regulation of these functions involved various coregulator complexes, such as the DRIP complex, SRC family, hairless (Hr), and β-catenin, each contributing differently to VDR-regulated activities. The review aimed to explore the mechanisms by which vitamin D and its receptor influence skin functions.
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