Vitamin D Dependent Rickets Type II (VDR-II): Response to Prolonged Therapy with Nocturnal Calcium Infusions
October 1990
in “
Pediatric Research
”
New to cholecalciferol? There is a guide in the encyclopedia. Read the guide → Studysummary This case report details a severe instance of VDR-II where intravenous calcium infusions, administered nightly, successfully improved clinical, radiological, and biochemical signs of rickets without alopecia despite ineffective calcitriol therapy.
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This report described a severe case of Vitamin D Dependent Rickets Type II (VDR-II) in a 3-year-old boy who showed resistance to high doses of calcitriol. Despite initial treatments with oral calcium, phosphate, and vitamin D3, the boy suffered from multiple pathological fractures. The study found that nocturnal intravenous calcium infusions, combined with oral phosphate, led to clinical, radiological, and biochemical improvements, including fracture healing. The treatment was effective and safe, and bone mineralization occurred without the biological activity of 1,25(OH)2D3. Notably, despite the severity of VDR-II, the patient did not develop alopecia.
