TLDR Nocturnal calcium infusions improved a boy's severe rickets without causing hair loss.
This report described a severe case of Vitamin D Dependent Rickets Type II (VDR-II) in a 3-year-old boy who showed resistance to high doses of calcitriol. Despite initial treatments with oral calcium, phosphate, and vitamin D3, the boy suffered from multiple pathological fractures. The study found that nocturnal intravenous calcium infusions, combined with oral phosphate, led to clinical, radiological, and biochemical improvements, including fracture healing. The treatment was effective and safe, and bone mineralization occurred without the biological activity of 1,25(OH)2D3. Notably, despite the severity of VDR-II, the patient did not develop alopecia.
2 citations
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July 2013 in “Journal of Life Sciences” A 2-year-old girl with a rare vitamin D disorder had rickets and hair loss, but treatment was ineffective due to poor compliance.
52 citations
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August 1993 in “Clinical endocrinology” Intravenous and oral calcium effectively treated vitamin D dependent rickets type II, improving growth and bone health.
July 2023 in “Journal of medical and health studies” A 3-year-old with vitamin D-resistant rickets and severe hair loss died despite treatment, highlighting the need for improved management of the condition.
107 citations
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March 2014 in “BoneKEy Reports” Mutations in the vitamin D receptor cause hereditary vitamin D-resistant rickets, leading to poor bone health and requiring high calcium doses for treatment.
151 citations
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June 2010 in “Endocrinology and metabolism clinics of North America” Two rare genetic diseases cause severe rickets in children due to defects in vitamin D metabolism.
24 citations
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November 2008 in “Arquivos Brasileiros de Endocrinologia & Metabologia” Four patients with a type of rickets and hair loss had different mutations in their vitamin D receptor gene, causing it to not work properly.
