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research Treatment of widespread alopecia areata in young patients with monthly oral corticosteroid pulse.

48 citations , July 1998 in “Pediatric Dermatology”

This study found that pulsed doses of prednisolone led to excellent hair growth in 60% of young patients with widespread alopecia areata, with minimal side effects.

research Treatment of Widespread Alopecia Areata in Young Patients with Monthly Oral Corticosteroid Pulse

18 citations , July 1998 in “Pediatric Dermatology”

This study observed that pulsed doses of prednisolone resulted in excellent hair growth in 60% of young patients with widespread alopecia areata after six months, with minimal side effects.

research BH06 (P075) A randomized controlled trial comparing the efficacy and safety of oral tofacitinib vs. methotrexate in moderate-to-severe alopecia areata

June 2025 in “British Journal of Dermatology”

This study compared oral tofacitinib and methotrexate in treating moderate-to-severe alopecia areata, finding that tofacitinib was more effective at reducing SALT scores and improving scalp hair assessment PRO scores, though both treatments reduced psychological distress similarly without serious adverse effects.

research P075 A randomized controlled trial comparing the efficacy and safety of oral tofacitinib vs. methotrexate in moderate-to-severe alopecia areata

June 2025 in “British Journal of Dermatology”

This study found that both tofacitinib and methotrexate effectively reduced hair loss and psychological distress in patients with moderate-to-severe alopecia areata, but tofacitinib showed much greater efficacy. Both treatments had similar safety profiles, with no serious adverse effects reported.

Optimization and Characterization of Cuscuta Reflexa Extract Loaded Phytosomes by the Box-Behnken Design to Improve the Oral Bioavailability

research Optimization and Characterization of Cuscuta reflexa Extract Loaded Phytosomes by the Box-Behnken Design to Improve the Oral Bioavailability

15 citations , January 2022 in “Journal of Oleo Science”

This study found that a phytosomal delivery system improved the bioavailability of Cuscuta reflexa extract compared to the plain extract, suggesting enhanced potential for this formulation.

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community What happened to that guy who’s been drinking topical minoxidil?!

in Chat 217 upvotes 1 year ago

A user tried various hair growth treatments, including drinking topical minoxidil, using oral minoxidil and finasteride, and applying GHK-Cu, growth hormone peptides, and liposomal sulforaphane. They experienced thicker hair, while others discussed the risks and benefits of these methods.

community Natural Remedies: Polyphenols and Hair Loss

20 upvotes 7 years ago

Natural remedies to treat hair loss, such as polyphenols, apple peel extract, grape seed extract, green tea extract, peppermint oil, pumpkin seed oil, apigenin, Ginkgo biloba, red clover extract, olive leaf extract, Ecklonia Cava and Grateloupia elliptica. In addition, terpenes, carotenoids, and tocopherols were discussed as potential treatments.

community Novel Formulation To Put An End To Hair Loss Once And For All.

in Research/Science 118 upvotes 10 months ago

A pharmacy student proposed a hair loss treatment using minoxidil, finasteride, clascoterone, and tretinoin, aiming for high effectiveness with minimal side effects. Reactions were mixed, with some questioning its feasibility and others showing interest.

community Creatine is the opposite of minoxidil !

324 upvotes 10 months ago

Creatine may counteract minoxidil's hair growth effects by closing potassium ATP channels, potentially leading to hair loss in predisposed individuals. Despite anecdotal reports, there is no conclusive evidence linking creatine to hair loss.

community New and Interesting HairLoss Studies/Papers/Reviews

44 upvotes 6 years ago

Hair loss treatments discussed include Dutasteride with Ketoconazole, tissue engineering strategies, and androgenetic alopecia therapies. Massage doubles follicular retention, improving treatment effectiveness.

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learn phosphorus

learn Overview

learn Finasteride

Topical or oral? Choosing between pills and lotions according to your case. Topical finasteride offers localized treatment with fewer systemic side effects than oral finasteride.

learn Metformin

Is metformin used topically for hair loss, or only as an oral tablet? Approved metformin products are oral tablets only; there is no approved topical metformin for hair loss. Published human reports of topical use are a handful of uncontrolled, pharmacy-compounded case reports in scarring alopecia, and the most-cited clinical series actually used the oral drug.

learn Sulforaphane

Is sulforaphane used in oral supplements or topical hair treatments? Sulforaphane is primarily used in oral supplements, not topical hair treatments.

learn white tea

Is white tea more effective in topical hair products or as an oral supplement for hair growth? Neither topical nor oral white tea has any human clinical trial behind it for hair growth. Topical use has a more direct mechanistic rationale, but the only verifiable studies are a cell-culture EGCG experiment and a pharmacokinetic study with no hair outcomes.

learn Estradiol

How does topical Estradiol compare to oral Estradiol in treating alopecia? Topical estradiol delivers hormone to the scalp with less systemic exposure, but evidence is thin and it is still a hormone. It needs a doctor's supervision, and people with estrogen-sensitive cancers must not use it without medical approval.

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