The Combined Use of Intravenous and Oral Calcium for the Treatment of Vitamin D Dependent Rickets Type II

    August 1993 in “ Clinical endocrinology ”
    Aida I. Al‐Aqeel, Pinar Özand, Samia H. Sobki, Wafa Al Sewairi, Stephen J. Marx
    TLDR Intravenous and oral calcium effectively treated vitamin D dependent rickets type II, improving growth and bone health.
    The study assessed the effectiveness of intravenous high-dose calcium infusions followed by high-dose oral calcium in treating vitamin D dependent rickets type II (VDDRII) in two siblings. The treatment normalized calcium and phosphate levels within 3-5 days and alkaline phosphatase and PTH levels within 15-20 months, with radiological healing observed in 42 days. The elder sister received daily infusions for 3-5 months, and the younger brother for 2 months, both followed by weekly infusions and maintenance on oral calcium. The treatment led to complete biochemical and radiological healing, improved height, and no evidence of nephrocalcinosis or kidney function deterioration. Early treatment was crucial for better growth and prevention of bone deformities, and it may also improve alopecia, though the mechanism requires further investigation.
    Discuss this study in the Community →

    Research cited in this study

    4 / 4 results

    Related Community Posts Join

    6 / 1000+ results

      community Alopecia Areata Question

      in Treatment  2 upvotes 3 years ago
      A user with alopecia totalis, borderline universalis, seeks advice on getting into a Xeljanz trial or appealing insurance for coverage. They experienced significant hair regrowth but are now seeing hair loss again and want to try Xeljanz.

      community mbp alopecia areata or vitamin deficiency

      in Chat 5 months ago
      A 19-year-old male has been using topical finasteride and minoxidil for 8 months with no progress and is considering seeking a second opinion due to potential misdiagnosis. The discussion revolves around whether the hair loss is due to male pattern baldness, alopecia areata, or a vitamin deficiency.

      community Androgenic alopecia exclusively on the vertex of the scalp

      in Chat  6 upvotes 7 months ago
      A user experienced androgenic alopecia starting at the vertex without frontal hairline recession and is seeking information on this pattern. Another user noted that vertex or diffuse hair loss is common among men.

      community Fibrosing alopecia in a pattern distribution

      in Research/Science  14 upvotes 9 months ago
      A user has been experiencing hair loss for 4 years, with treatments like minoxidil, finasteride, and various supplements proving ineffective. They were diagnosed with fibrosing alopecia in a pattern distribution, a condition that may require a combination of anti-inflammatory and hair growth treatments.

      community Androgenetic alopecia is a skin disease: DHT-mediated skin disorders

      in Research/Science  65 upvotes 1 year ago
      Dihydrotestosterone (DHT) impacts various skin conditions, including Androgenetic alopecia and seborrheic dermatitis, by causing overactivity in sebaceous glands. Topical medications Tacrolimus and Clobetasol can reduce these inflammatory conditions, and treatments like RU58841, Minoxidil, and Finasteride may also be beneficial.

    Similar Research

    6 / 1000+ results