21 citations
,
January 2013 in “Annals of dermatology/Annals of Dermatology” In this study, combination therapy with cyclosporine and PUVA for severe alopecia areata resulted in a majority of patients showing only fair to poor responses, though some improvements were noted.
21 citations
,
August 1984 in “BJOG An International Journal of Obstetrics & Gynaecology” This study found no differences in ovarian function between renal transplant recipients treated with either cyclosporin A or azathioprine and prednisone, although excessive hair growth was common in both groups.
20 citations
,
July 2009 in “Experimental and Clinical Endocrinology & Diabetes” This study found that increased hair growth from Cyclosporin A treatment is likely not due to hormonal changes.
20 citations
,
October 2003 in “The Journal of Dermatology” This study observed that while dexamethasone-cyclophosphamide pulse therapy is relatively free from hypertension and diabetes compared to conventional steroids in pemphigus patients, it frequently causes generalized weakness and flushing.
20 citations
,
January 1995 in “Journal of Dermatological Science” This study found that topical application of cyclosporin A and FK506 induces new hair growth in mice, while ascomycin and rapamycin do not, suggesting hair induction is not due to immunosuppression.
20 citations
,
March 1990 in “Archives of Dermatology” This study suggests that cyclosporine may directly affect epithelial cell growth, potentially leading to broader use of its nonimmunosuppressive analogues in treating hyperproliferative epidermal diseases.
19 citations
,
March 1975 in “British Journal of Dermatology” This study presents a method for extracting and measuring cyclic AMP in small amounts of skin tissue, finding varying levels in the dermis, epidermis, and hair follicles.
18 citations
,
March 2014 in “Drug Development and Industrial Pharmacy” This study evaluated new aqueous gel formulations of minoxidil without irritants and found that the calcium alginate gel showed the best performance in terms of drug release and skin permeation.
18 citations
,
March 2002 in “The journal of investigative dermatology/Journal of investigative dermatology” In this study, 17β-estradiol increased VEGF production in differentiated THP-1 cells, while dihydrotestosterone counteracted this effect by modulating adenylate cyclase activity.
18 citations
,
March 1990 in “Archives of Dermatology” This case report describes the successful treatment of severe bullous erythema multiforme in a patient using cyclosporine, where prior high-dose corticosteroids had only partially worked.
17 citations
,
August 1971 in “Journal of Investigative Dermatology” This study observed that enzyme activity influencing estradiol-to-estrone conversion in Wistar rat skin varied with the hair cycle in dorsal skin but was minimal in plantar skin.
16 citations
,
June 2015 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that DHHC13 is crucial for hair anchoring and skin barrier function, with its deficiency in Zdhhc13(skc4) mice leading to cyclic alopecia and skin abnormalities due to cornifelin deficiencies.
16 citations
,
July 1989 in “British journal of dermatology/British journal of dermatology, Supplement” Topical cyclosporin A doesn't work for alopecia totalis because it doesn't penetrate the skin well.
15 citations
,
January 1998 This study found that repeated cycles of wetting and blow-drying hair fibers can cause cracks in the hair cuticles, particularly among individuals who frequently blow-dry their hair.
15 citations
,
November 1997 in “Australasian Journal of Dermatology” This report describes a case where a patient with acute generalized pustular psoriasis achieved remission using a combination of oral cyclosporin and PUVA therapy, maintaining remission 12 months after stopping treatment.
14 citations
,
July 2016 in “Environmental Toxicology and Pharmacology” In this animal study, cedrol treatment reduced chemotherapy-induced alopecia in mice by preventing hair follicle damage, while minoxidil did not prevent alopecia under similar conditions.
14 citations
,
January 2016 in “Annals of dermatology/Annals of Dermatology” This study found that oral cyclosporine was more effective and had fewer side effects than betamethasone minipulse therapy for treating alopecia areata.
14 citations
,
January 2015 in “Annals of dermatology/Annals of Dermatology” This study found that corticosteroid pulse therapy may be more effective than oral cyclosporine with corticosteroid for patients with severe alopecia areata, especially for those with the plurifocal type or a short disease duration.
13 citations
,
April 2020 in “Dermatology and therapy” This systematic review assessed cyclosporine's effectiveness with or without corticosteroids for treating alopecia areata, finding combined therapy more effective and with a lower recurrence rate than monotherapy, especially for severe cases, though results varied by alopecia type.
13 citations
,
January 2013 in “Applied and Environmental Microbiology” This study found that regio-specific hydroxylation of cyclosporine A in Sebekia benihana is mediated by the cytochrome P450 hydroxylase CYP-sb21, suggesting potential biotechnological applications for hair growth promotion without immunosuppressive effects.
12 citations
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August 2020 in “JEADV. Journal of the European Academy of Dermatology and Venereology/Journal of the European Academy of Dermatology and Venereology” This study found that most chronic alopecia areata patients treated with azathioprine, methotrexate, or cyclosporine continued treatment for at least 12 months, often requiring concurrent low-dose prednisolone.
12 citations
,
January 2004 in “International Journal of aromatherapy/International journal of aromatherapy” This study found that Ocimum gratissimum essential oil may enhance hair growth and promote follicular proliferation in rats experiencing cyclophosphamide-induced hair loss.
12 citations
,
November 1996 in “Australasian journal of dermatology” A kidney transplant patient on cyclosporin experienced unexpected severe hair loss, which improved with treatment adjustments.
11 citations
,
July 2014 in “Clinical Rheumatology” This study found that Chinese female patients with systemic autoimmune diseases treated intravenously with cyclophosphamide were more likely to experience gastrointestinal discomfort, myelosuppression, and alopecia.
11 citations
,
September 2012 in “Journal of Nanjing Medical University” In this study, cyclosporine A stimulated hair growth in mouse vibrissae organ culture by promoting matrix cell proliferation and altering growth factor expression.
11 citations
,
March 2010 in “PubMed” This study concluded that monthly pulse IV cyclophosphamide therapy was effective in achieving complete or partial remission in 68.9% of Indian patients with severe lupus nephritis, though longer follow-up is needed.
10 citations
,
January 2020 in “Genes & Diseases” In this study, circ-Smad5 was found to inhibit the proliferation and cell cycle progression of JB6 cells by suppressing Wnt/β-catenin/Lef 1 signaling activation, marking the first report of its function.
10 citations
,
December 2013 in “The journal of investigative dermatology. Symposium proceedings/The Journal of investigative dermatology symposium proceedings” This case report describes a patient with severe alopecia areata and multiple autoimmune diseases who showed excellent hair regrowth after treatment with prednisone and cyclosporine, though she later developed hyperpigmentation.
10 citations
,
July 1994 in “Journal of Dermatological Science” In this study, cyclosporin was found to prolong the hair-existing phase in nude mice, while corticosteroids inhibited its effect and suppressed hair regrowth.
10 citations
,
August 1990 in “Journal of Steroid Biochemistry” High doses of cyclosporine A increase testosterone conversion, possibly boosting hair growth.