Micro-Determination of Cyclic AMP Levels in Human Epidermis, Dermis, and Hair Follicles

    March 1975 in “ British Journal of Dermatology ”
    Kenji Yoshikawa, Kenji Adachi, Victor Levine, Kenneth M. Halprin
    TLDR A new method accurately measures cyclic AMP levels in small skin and hair samples.
    The study developed a method to measure cyclic AMP levels in small samples (50-100 µg) of human epidermis, dermis, and hair follicles. By adapting Gilman's method, researchers were able to extract cyclic AMP and remove contaminants from these tissues. The cyclic AMP levels were found to be approximately 1 pmol/µg in the dermis, 2 pmol/µg in the epidermis, and 3-5 pmol/µg in hair follicles. This method was applicable for analyzing cyclic AMP in both healthy and diseased skin.
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