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    Did you mean Cutaneous Squamous Cell Carcinoma?
    Glossary Cutaneous Squamous Cell Carcinoma

    type of skin cancer originating in outer squamous cells

    Cutaneous Squamous Cell Carcinoma (cSCC) is a type of skin cancer that originates in the squamous cells, which are flat cells located in the outer layer of the skin (epidermis). It often appears as a red, scaly patch, open sore, or wart-like growth that may crust or bleed, and it can develop on sun-exposed areas of the body. If left untreated, cSCC can grow larger and potentially spread to other parts of the body, making early detection and treatment crucial.

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    1. miR-22 promotes stem cell traits via activating Wnt/β-catenin signaling in cutaneous squamous cell carcinoma Oncogene · 2021 · 30 citations
    2. Genetic deletion of TNFα inhibits ultraviolet radiation-induced development of cutaneous squamous cell carcinomas in PKCε transgenic mice via inhibition of cell survival signals Carcinogenesis · 2015 · 11 citations
    3. Reduced SMAD2/3 activation independently predicts increased depth of human cutaneous squamous cell carcinoma Oncotarget · 2018 · 11 citations
    4. Clinically relevant aberrant Filip1l DNA methylation detected in a murine model of cutaneous squamous cell carcinoma EBioMedicine · 2021 · 7 citations
    5. Regulation and Role of GLI1 in Cutaneous Squamous Cell Carcinoma Pathogenesis Frontiers in genetics · 2019 · 6 citations
    6. Invasive cutaneous squamous cell carcinoma of scalp: A case report Annals of Medicine and Surgery · 2022 · 2 citations
    7. MmuPV1-Induced Cutaneous Squamous Cell Carcinoma Arises Preferentially from Lgr5+ Epithelial Progenitor Cells Viruses · 2022 · 2 citations
    8. High-risk cutaneous squamous cell carcinoma in a Japanese allogeneic bone marrow transplant recipient on long-term voriconazole The Journal of Dermatology · 2017 · 2 citations
    9. Successful in situ 5-aminolevulinic acid photodynamic therapy in a 53-year-old female with cutaneous squamous cell carcinoma Journal of Zhejiang University SCIENCE B · 2025 · 1 citations
    10. GSDMA deficiency impairs cutaneous squamous cell carcinoma growth Frontiers in Oncology · 2026
    11. Calcineurin/Nuclear Factor of Activated T-Cell Pathway in Cutaneous Squamous Cell Carcinoma International journal of dermatology and venereology · 2019
    12. Is Three-Dimensional Virtual Planning in Cranial Reconstruction for Advanced Cutaneous Squamous Cell Carcinoma of the Skull a Feasible Option? Journal of Craniofacial Surgery · 2019 · 1 citations
    13. Increased Risk of Local Recurrence in Cutaneous Squamous Cell Carcinoma Arising in Sun-Exposed Skin: A Retrospective Cohort Study Cancers · 2023
    14. Postoperative Radiotherapy for Cutaneous Squamous Cell Carcinoma in Patients With Microscopic Residual Disease JAMA Dermatology · 2020 · 2 citations
    15. Alopecia Areata in a Patient Receiving Cemiplimab for Metastatic Cutaneous Squamous Cell Carcinoma JEADV Clinical Practice · 2026
    16. When Rare Meets Risky: Clouston Syndrome with Cutaneous Squamous Cell Carcinoma Indian Dermatology Online Journal · 2025
    17. Multi-omics analysis unveils the role of cancer-associated fibroblasts in cutaneous squamous cell carcinoma Cancer Cell International · 2025
    18. Novel small molecules downregulate CDK1 expression and inhibit Wnt/β-catenin signaling in cutaneous squamous cell carcinoma by targeting its distinct tumor-specific cellular landscape Experimental & Molecular Medicine · 2025
    19. Cutaneous Squamous Cell Carcinoma of the Head and Neck: A Retrospective Analysis of Loco-Regional Recurrences and Survival Rates Over a Consecutive 10-Year Period Cureus · 2024
    20. Alterations in Endogenous Retinoids with Acute UVB Exposure and in the Progression of Cutaneous Squamous Cell Carcinoma OhioLink ETD Center (Ohio Library and Information Network) · 2015
    21. Protein Kinase C Epsilon Signals Ultraviolet Light‐induced Cutaneous Damage and Development of Squamous Cell Carcinoma Possibly Through Induction of Specific Cytokines in a Paracrine Mechanism<sup>¶</sup> Photochemistry and Photobiology · 2005 · 3 citations
    22. Primary Cutaneous Rhabdoid Squamous Cell Carcinoma: A Case Report and Review of Molecular Features Cureus · 2024 · 1 citations
    23. Distinct transcriptomic landscapes of cutaneous basal cell carcinomas and squamous cell carcinomas Genes & Diseases · 2019 · 31 citations
    24. Distinct transcriptomic landscapes of cutaneous basal cell carcinomas and squamous cell carcinomas Publisher · 2019
    25. Protein Kinase C Epsilon Signals Ultraviolet Light-induced Cutaneous Damage and Development of Squamous Cell Carcinoma Possibly Through Induction of Specific Cytokines in a Paracrine Mechanism¶ Photochemistry and Photobiology · 2005 · 28 citations
    26. Response of Cutaneous Squamous Cell Carcinoma to Treatment With Cetuximab Dermatologic Surgery · 2018 · 1 citations
    27. Protein Kinase Cε, which Sensitizes Skin to Sun's UV Radiation–Induced Cutaneous Damage and Development of Squamous Cell Carcinomas, Associates with Stat3 Cancer Research · 2007 · 76 citations
    28. 129 Genetic transformation of keratoacanthoma-type cutaneous squamous cell carcinoma following intralesional chemotherapy Journal of Investigative Dermatology · 2018 · 2 citations
    29. 44088 Clinical characteristics, treatment, and outcomes in patients with cutaneous squamous cell carcinoma of the scalp and ear at a reference center in Mexico Journal of The American Academy of Dermatology · 2023
    30. 0749 Serine and arginine-rich splicing factor 3 regulates epidermal differentiation in cutaneous squamous cell carcinoma Journal of Investigative Dermatology · 2025