January 2013 in “Shanghai Textile Science & Technology” This study found that milk protein grafting and cross-linking treatment significantly improved the pilling resistance of rabbit hair knitted fabric.
June 2025 in “ACS Biomaterials Science & Engineering” In this study, researchers developed a new microneedle patch delivery system for minoxidil, which enhanced its controlled release and improved hair growth in mice, potentially offering better treatment outcomes for androgenetic alopecia.
July 2023 in “Nature Reviews Chemistry” A new method strengthens hair without using harmful chemicals.
9 citations
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September 2022 in “Journal of Clinical Investigation” In this study, mouse models of 22q11.2 deletion syndrome showed that growth issues in small embryonic thymuses were linked to mesenchymal cells, which could be corrected by substituting with normal mesenchyme.
December 2025 in “Materials Technology” In this laboratory study, researchers developed a genipin-stabilized asymmetric PLA/gelatin scaffold that mimics skin architecture, supports fibroblast proliferation, and closes scratches effectively, suggesting its potential for epidermal-dermal regeneration and applications in sensing or drug delivery.
January 2026 in “RSC Advances” The hydrogel helps heal wounds without scars by releasing two drugs gradually.
December 2024 in “Macromolecular Bioscience” This study reports that a novel UV-based crosslinking process for collagen sponges significantly decreases crosslinking time compared to traditional methods, and supports effective cell proliferation and wound regeneration in a mouse model, without causing abnormal angiogenic or immune responses.
11 citations
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September 1996 in “Journal of applied polymer science” In this study, treatment with aqueous KCN selectively converted disulfide bonds to monosulfide crosslinks in hair, leading to changes in microstructural properties and rubberlike elasticity under specific laboratory conditions.
7 citations
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May 2024 in “Gels” This study evaluated a new collagen and tannic acid hydrogel in rat liver and heart bleeding models, finding it reduced blood loss and hemostatic time compared to commercial products, with benefits such as enhanced biodegradability and potential for clinical use.
April 2025 in “Pharmaceuticals” This study found that novel thiol-reactive cross-linking agents, particularly APA, significantly improved the tensile strength and elasticity of human hair fibers by effectively regenerating disulfide bridges, with potential applications for advanced hair repair treatments in the cosmetic industry.
4 citations
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June 2022 in “Journal of cleaner production” This study found that a new eco-friendly hair crosslinking method using visible light and non-toxic chemicals caused less damage and improved mechanical properties compared to traditional thioglycolic acid treatment.
61 citations
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January 2013 in “International Journal of Biological Macromolecules” This study found that applying both dehydrothermal treatment and carbodiimide crosslinking improved the mechanical properties of porcine acellular dermal matrix scaffolds without added cytotoxicity, suggesting potential applications in tissue engineering.
This study found that a bio-based repair solution containing hydrolysed wool keratin, serine, and transglutaminase improved the physical and chemical properties of damaged hair, increasing its strength, flexibility, and thermal stability while offering long-lasting protection against chemical damage.
December 2025 in “Cosmetics” In a laboratory study, researchers found that a novel Bioactive Crosslink Repair Complex improved both the protection and repair of chemically damaged hair, enhancing tensile strength, shine, and cuticle alignment when added to bleaching mixtures and leave-in conditioners.
September 2025 in “International Journal of Biological Macromolecules” In an animal study with a skin defect model, this research reported that curcumin-loaded hydrogels made from recombinant humanized collagen and an eco-friendly crosslinker enhanced wound repair by promoting angiogenesis, granulation tissue formation, and hair follicle neogenesis, while providing antioxidant benefits.
10 citations
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September 2020 in “Biopolymers” This study found that bleached hair showed optimal protein structural integrity and tensile strength at pH 5, with significant changes in cross-linking, water content, and diameter at more alkaline or acidic levels.
November 2023 in “Global journal of medical research” This study highlights the importance of understanding the rheological properties of hyaluronic acid fillers, including viscosity, cross-linking, and concentration, to optimize their use in addressing facial aging by maximizing clinical effects.
13 citations
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July 2017 in “Biopolymers” This study presents recombinant human hair keratins K31 and K81, observing novel nanostructures from their self-assembly and emphasizing disulfide crosslinking's role in this process.
2 citations
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October 2020 in “Journal of Pharmacology and Experimental Therapeutics” This study found that in a mouse model of bronchopulmonary dysplasia, minoxidil administered at 50 mg/kg/day did not impact lung development or inhibit lysyl hydroxylation.
28 citations
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January 2016 in “RSC Advances” This study found that non-toxic polycarboxylic acids can achieve satisfactory hair perming effects with limited strength loss, suggesting they have potential as a safer alternative to harmful perming chemicals.
24 citations
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October 2019 in “Genes” In this study, the identification of a novel KAP gene in sheep, named KRTAP36-1, was associated with increased prickle factor in wool, suggesting its potential as a genetic marker for breeding purposes.
28 citations
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November 2020 in “Polymers” This study found that crosslinking buffalo gelatin with different methods can modify its properties and potential as a skin substitute, though double-crosslinking may increase immunogenicity slightly.
122 citations
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January 2006 in “Molecular & Cellular Proteomics” This study found that keratin and other hair proteins in humans are extensively modified posttranslationally, which helps explain the structural characteristics of mature hair.
August 2023 in “International Journal of Molecular Sciences” In this study, researchers developed a new sodium alginate/chitosan/Zn2+ hydrogel that showed improved physical properties, antibacterial activity, and biocompatibility, and demonstrated enhanced wound healing and skin regeneration in an in vitro model.
31 citations
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August 2023 in “ACS Applied Bio Materials” This study developed granular hydrogels with reversible interparticle cross-linking, finding they offer high mechanical stability and enhance cell recruitment, making them promising for injectable and 3D printable scaffolds in tissue engineering and therapeutic delivery.
4 citations
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January 2015 in “Sen'i Gakkaishi” This study proposed a network model for the cross-linked structure of keratin-associated proteins in hair and wool fibers, suggesting notable differences between the two, potentially affecting hair fiber elasticity.
1 citations
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March 2023 in “Journal of Natural Fibers” This study explored using tyrosine as a cross-linking agent for curling Asian hair and found that it could shape hair effectively before washing without damaging the fibers, though the method was less effective after washing compared to commercial products.
3 citations
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July 2025 in “Gels” This review explores how recombinant protein hydrogels, employing molecular engineering and crosslinking strategies, offer advanced applications in regenerative medicine by mimicking extracellular matrix dynamics and providing enhanced mechanical, environmental, and biological properties.
91 citations
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December 2000 in “The journal of cell biology/The Journal of cell biology” This study reports that expressed mouse type Ia and type IIa trichocyte keratins were successfully assembled into intermediate filaments in vitro, while also suggesting that disulfide bond cross linking enhances their stability.
6 citations
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August 2024 in “Biomacromolecules” This study introduces a novel in vitro model for clubfoot fibrosis to enable high-throughput drug screening and found that while the model increased collagen deposition, the antifibrotic drug minoxidil effectively inhibited the expression of collagen cross-linking enzymes.