Dynamically Cross-Linked Granular Hydrogels for 3D Printing and Therapeutic Delivery

The study investigates the development of dynamically cross-linked granular hydrogels using hydrazone bonds for improved 3D printing and therapeutic delivery. These hydrogels, made from methacrylate-modified chondroitin sulfate, exhibit shear-thinning and self-healing properties, making them suitable for injectable and 3D-printed tissue scaffolds. The research highlights their high porosity and ability to sustain protein delivery, supporting tissue regeneration and cell recruitment. The hydrogels demonstrate superior mechanical stability and structural integrity, maintaining their form under compression and recovering mechanical properties after extrusion. These characteristics, along with their potential for sustained protein release, make them promising for biomedical applications, including tissue engineering and regenerative medicine.