A Novel Crosslinking Approach for Biomanufacturing of a Collagen-Based Skin Dermal Template

December 2024 in “ Macromolecular Bioscience ”

Weng Wan Chan, Kaushik Roy, Bach Quang Le, Hariharan Ezhilarasu, Xiaoqian Zhang, Ryan G. Lim, Avinanda Banerjee, Moni Abraham Kuriakose, Kimmie Ng, Priya Murugan, Chun Ting Goh, Weibiao Zhou, May Win Naing, Srikala Raghavan, Deepak Choudhury

collagen-based skin dermal template UV irradiation glutaraldehyde human dermal fibroblast cells full-thickness skin wounds Integra template angiogenic responses immune responses collagen sponge scaffold third-degree burns collagen sponge skin template burn treatment

Studysummary This study reports that a novel UV-based crosslinking process for collagen sponges significantly decreases crosslinking time compared to traditional methods, and supports effective cell proliferation and wound regeneration in a mouse model, without causing abnormal angiogenic or immune responses.

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research Biofabrication of Human Skin with Its Appendages

10 citations , September 2022 in “Advanced Healthcare Materials”

This review discusses recent advancements and ongoing challenges in engineering human skin with appendages using scaffold-free and scaffold-based bioengineering approaches, but it reports no new clinical results.