Mechanism of Hair Curling via Laccase-Assisted Tyrosine Grafting Using BSA as a Model Protein

    March 2023 in “ Journal of Natural Fibers ”
    Yu Li, Jing Su, Tarsila G. Castro, Artur Cavaco‐Paulo
    TLDR A gentler, less damaging method for curling hair using tyrosine works well initially but fades after washing.
    This study explores a gentler method for hair curling using tyrosine as a crosslinking agent, which avoids the harsh chemicals typically used in commercial perming. By using bovine serum albumin (BSA) as a model protein, researchers demonstrated that tyrosine can effectively form new cross-linked peptides between thiols and amines. The process involves reducing disulfide bonds with L-cysteine and then using laccase-assisted grafting with tyrosine. The optimized conditions for curling Asian hair involved a pretreatment with 50.0 mM L-cysteine followed by 3.0 mM tyrosine, resulting in better initial perming performance compared to commercial products, although the effect diminished after washing. This method does not weaken hair fibers and can be easily achieved with a blow-drier, suggesting a potential for a more user-friendly and less damaging hair perming technique.
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