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The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

Overexpressing the mineralocorticoid receptor in mouse skin causes skin thinning, early skin barrier development, eye issues, and hair loss.

Graft-versus-host disease is a complication where donor immune cells attack the recipient's body, often affecting the skin, liver, and gastrointestinal tract.

Different tea tree oil mixtures absorb into hair follicles at varying levels, with microemulsion being the most effective.

EGF and KGF signalling prevent hair follicle formation and promote skin cell development in mice.

Antiviral medication valganciclovir may improve skin and hair in Trichodysplasia Spinulosa patients.

Hair follicle cells help maintain and support stem cells and blood cell formation.

A scalp biopsy revealed systemic amyloidosis in a woman who initially seemed to have a common hair loss condition.

A diet high in vitamin E improved blood health, skin, and fur in common marmosets.

Combination therapy of doxazosin and finasteride safely and effectively reduces benign prostatic hyperplasia progression risk.

Prostate cancer was a major health issue in 2009, especially for Black men, and targeting the 5alpha-reductase enzyme could help in its prevention and treatment.

Interferon and ribavirin can cause serious skin reactions and other health issues.

Individuals with male pseudohermaphroditism often do better raised as females with early surgery.

Ingesting Leucaena leucocephala caused hair loss and increased infant mortality in ringtailed lemurs.

Dutasteride is effective for treating prostate enlargement and reducing related surgery risk, but is not approved for preventing prostate cancer.

MFN2 mutations cause mitochondrial problems, leading to more upper body fat and lower leptin levels.

The dog likely has a condition similar to Canine alopecia X.

Retinoids change the fat content in skin oil and reduce bacteria growth, helping to treat acne.

Cuticle damage doesn't affect hair's tensile strength; the cortex is responsible for it.

Finasteride lowers risk of urinary issues and surgery by over 50% in 4 years.

The p53 protein has complex, sometimes contradictory functions, including tumor suppression and promoting cell survival.

A rare scalp condition causing hair loss and cysts in young men can be treated effectively with a specific steroid injection.

Combining flutamide and finasteride can reduce prostate weight and tumor growth, potentially benefiting treatments needing optimal DHT inhibition.

Finasteride reduces urinary issues and surgery need in men with enlarged prostates by over 50%.

Terazosin and finasteride effectively treat BPH, but combining them adds no extra benefit.

Human skin can make serotonin and melatonin, which help protect and maintain it.

Calreticulin has roles in healing, immune response, and disease beyond its known functions in the endoplasmic reticulum.

Women with the NIH type of PCOS have more obesity and higher risk of diabetes and heart disease than those with other types of PCOS.

Chemicals and body size might change when puberty starts and progresses, but more research is needed to confirm this.

Chemotherapy can cause various skin reactions, with hair loss being the most common, and proper diagnosis and treatment of these reactions are important.