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Gene therapy, especially using atoh1, shows promise for creating functional sensory hair cells in the inner ear, but dosing and side effects need to be managed for clinical application.

The Wnt signaling pathway is not a major factor in the development of keratoacanthoma, a type of skin tumor.

Breast cancer treatments work better with AR activation, improving results and reducing side effects.

Blocking neurosteroid production can lead to more seizures and faster epilepsy onset in rats.

The document concludes that understanding sulfation biology is crucial for creating treatments due to its importance in biological functions and disease.

Researchers found potential new targets for treating melanoma and nonmelanoma skin cancers, and identified a possible cause and treatment for male pattern baldness and eczema.

Some existing medicines show promise as safe treatments to protect against the side effects of radiation therapy.

New hair loss treatments may include topical medications, injections, and improved transplant methods.

Betamethasone dipropionate reduced skin thickness, fish oil increased it, and combined treatment had no significant effect.

Essential oils from Curcuma species, like turmeric, have compounds that can fight inflammation, cancer, and bacteria, and can also stimulate hair regrowth in bald males.

Young women with PCOS have a higher risk of high blood pressure and metabolic syndrome, but these risks may decrease after age 40.

Skin cells produce and activate vitamin D, which regulates skin functions and supports hair growth.

Neuroactive steroids show promise for treating mental and neurological disorders by targeting GABA_A receptors.

Janus kinase inhibitors are promising treatments for autoimmune skin diseases like eczema and psoriasis.

Minoxidil boosts hair growth by opening potassium channels and increasing cell activity.

Tamsulosin for enlarged prostate may increase the risk of severe low blood pressure, especially when starting or restarting the medication.

Herbal compounds like ricinoleic acid, quercetin-3-O-rutinoside, and hinokiflavone may be safe and effective for treating hair loss.

Studying premature aging syndromes helps understand human aging and suggests potential treatments.

The BMP/Smads pathway and Id2 gene control hair follicle stem cells, affecting their rest and growth phases.

Men taking 5-alpha-reductase inhibitors before or after bladder cancer diagnosis had a lower risk of dying from the disease.

Optimal long-acting finasteride injection dose found: 16.8 mg, effective for one month.

Different species and human skin models vary in their skin enzyme activities, with pig skin and some models closely matching human skin, useful for safety assessments and understanding the skin's protective roles.

Retinoic acid-binding proteins in skin are regulated by β-catenin and Notch signalling.

Stopping S100A3 activity slows down hair growth in mice.

Rapamycin treatment helps with mitochondrial disease by reducing PKC levels.

The document concludes that inhalation of oxygen and sumatriptan injections are primary for cluster headaches, indomethacin for paroxysmal hemicrania, and lidocaine and lamotrigine for SUNCT, but SUNCT often resists treatment.

Bioassays help find useful compounds in nature for making medicines, supplements, and cosmetics.

Stronger corticosteroids cause more skin damage in hairless dogs, similar to effects in humans.

The document concludes that for hair and feather growth, it's better to target the environment around stem cells than the cells themselves.