research A Discourse on Human Hair Fibers and Reflections on the Conservation of Drug Molecules
Hair analysis for drugs needs a better understanding of how drugs enter hair, considering factors like hair structure and pigmentation.
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research Overexpression of Activin A in the Skin of Transgenic Mice Reveals New Activities in Epidermal Morphogenesis, Dermal Fibrosis, and Wound Repair
Overexpression of activin A in mice skin causes skin thickening, fibrosis, and improved wound healing.
research Development and Homeostasis of the Skin Epidermis
The skin protects the body and is constantly renewed by stem cells; disruptions can lead to cancer.
research Skin and Hair: Models for Exploring Organ Regeneration
Skin and hair can help us understand organ regeneration, especially how certain stem cells might be used to form new organs.
research Loss of Keratin K2 Expression Causes Aberrant Aggregation of K10, Hyperkeratosis, and Inflammation
Loss of keratin K2 causes skin problems and inflammation.
research Multiple Roles of Integrin-Linked Kinase in Epidermal Development, Maturation, and Pigmentation Revealed by Molecular Profiling
ILK is essential for skin development, pigmentation, and healing.
research Deletion of Hypoxia-Inducible Factor Prolyl 4-Hydroxylase 2 in FoxD1-Lineage Mesenchymal Cells Leads to Congenital Truncal Alopecia
Removing a specific gene in certain skin cells causes hair loss on the body by disrupting normal hair development.
research Beta-Caryophyllene Enhances Wound Healing Through Multiple Routes
Beta-caryophyllene helps improve wound healing in mice, especially in females.
research AP-2α/AP-2β Transcription Factors Are Key Regulators of Epidermal Homeostasis
AP-2α and AP-2β proteins are essential for healthy adult skin and hair.
research Laminin 332 Is Indispensable for Homeostatic Epidermal Differentiation Programs
Laminin 332 is essential for normal skin cell behavior and structure.
research Immunolocalization of Scaffoldin, a Trichohyalin-Like Protein, in the Epidermis of the Chicken Embryo
Scaffoldin helps form hard skin structures in chicken embryos.
research Impaired Wound Healing in Transgenic Mice Overexpressing the Activin Antagonist Follistatin in the Epidermis
Overexpressing follistatin in mice delays wound healing and reduces scar size.
research Transcriptome Meta-Analysis Confirms the Hidradenitis Suppurativa Pathogenic Triad: Upregulated Inflammation, Altered Epithelial Organization, and Dysregulated Metabolic Signaling
The research confirms that Hidradenitis Suppurativa is characterized by increased inflammation, disrupted skin cell organization, and abnormal metabolic processes.
research Cell Death in Skin Function, Inflammation, and Disease
Different types of cell death affect skin health and inflammation, and understanding them could improve treatments for skin diseases.
research Trichohyalin-Like Proteins Have Evolutionarily Conserved Roles in the Morphogenesis of Skin Appendages
Trichohyalin-like proteins are essential for the development of skin structures like hair, nails, and feathers.
research Hair Loss Caused by Gain-of-Function Mutant TRPV3 Is Associated with Premature Differentiation of Follicular Keratinocytes
A gene mutation causes early keratinocyte maturation leading to hair loss in Olmsted syndrome.
research Epidermal Homeostasis: A Balancing Act of Stem Cells in the Skin
Skin stem cells are crucial for maintaining and repairing the skin and hair, using a complex mix of signals to do so.
research Thyroid Hormone Action on Skin
Thyroid hormones affect skin texture, hair and nail growth, and can cause skin diseases related to thyroid problems.
research Cyclooxygenases in the Skin: Pharmacological and Toxicological Implications
Blocking COX, especially COX-2, in the skin can reduce inflammation and pain and may help prevent skin cancer.
research Liposomes in Cosmeceuticals
Liposomes could improve how skin care products work but are costly and not very stable.
research Cloning of Wrinkle-Free, a Previously Uncharacterized Mouse Mutation, Reveals Crucial Roles for Fatty Acid Transport Protein 4 in Skin and Hair Development
Fatty acid transport protein 4 is essential for skin and hair development.
research Anatomy and Function of the Skin
The skin is the largest organ, protecting the body, regulating temperature, and producing hormones.
research In Silico Analysis of Gene Expression Data from Bald Frontal and Haired Occipital Scalp to Identify Candidate Genes in Male Androgenetic Alopecia
Found 32 genes linked to male baldness, affecting hair growth and stress-related pathways.
research Preparing the Hair Follicle Canal for Hair Shaft Emergence
A specific type of skin cell creates an opening for hair to grow out, and problems with this process can lead to skin conditions.
research Structure and Development of the Skin and Cutaneous Appendages
Understanding skin structure and development helps diagnose and treat skin disorders.
research Basal Cells in the Epidermis and Epidermal Differentiation
The exact identity of skin stem cells and how skin cells differentiate is not fully known.
research Cornification
Cornification is the process where living skin cells die to create a protective barrier, and problems with it can cause skin diseases.
research Integration of Biochemical and Mechanical Signals at the Nuclear Periphery: Impacts on Skin Development and Disease
The conclusion is that the nuclear lamina and LINC complex in skin cells respond to mechanical signals, affecting gene expression and cell differentiation, which is important for skin health and can impact skin diseases.
research Skin, Genetic Defects, and Aging
Genetic defects and UV radiation cause skin damage and aging.
research Scratching the Surface of Skin Development
The document concludes that skin stem cells are important for hair growth and wound healing, and could be used in regenerative medicine.