This study found that a skin-like structure can be generated in vitro by implanting early passage hair follicle bulb cells into collagen/chitosan porous scaffolds.
January 2006 in “Chinese Journal of Dermatology” In this study, researchers found that hair follicle-like structures can be generated from collagen/chitosan porous scaffolds implanted with mouse hair follicle cells in vitro.
April 2024 in “Authorea (Authorea)” This review summarizes techniques like Raman spectroscopy, nanoindentation, and small-angle X-ray scattering to explore the biophysical interactions in collagen fibers, aiming to enhance understanding of fibroblast behavior and mechanisms involved in organ fibrosis and healing processes.
May 2026 in “Frontiers in Cell and Developmental Biology” In this study, researchers suggest that hair follicle miniaturization in conditions like androgenetic alopecia may result from impaired conversion of quiescent stem cells to progenitor cells, influenced by the follicular niche, its collagen network, and various mechanical constraints.
31 citations
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June 2022 in “Scientific Reports” This study presents a method using polarization-sensitive optical coherence tomography to accurately assess the depth of burn wound damage in the dermal collagen matrix, potentially improving diagnosis beyond traditional visual methods.
22 citations
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February 2013 in “Wound Repair and Regeneration” In this study, CD109 overexpression in transgenic mice led to reduced inflammation and improved collagen organization during wound healing without affecting wound closure.
7 citations
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June 2001 in “PubMed” This study details the histological structure of the white domesticated pig's ear skin and discusses its relevance as a model for human dermatological research.
3 citations
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October 1994 in “Medical Molecular Morphology” This study observed that the lower part of vibrissa hair roots in adult Wistar rats receives a richer blood supply and structural protection, compared to the upper part.
1 citations
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April 2017 in “Journal of Investigative Dermatology” This study evaluated the effects of topical glucocorticoids on human skin using non-invasive imaging methods and observed changes such as alterations in skin layer thickness, keratinocyte size, and collagen and elastin signal intensity.
March 2015 in “Plastic and reconstructive surgery” This chapter reviews the skin's structure and its clinical relevance, highlighting connective tissue diseases and the potential for novel treatments like protein, cell, or stem cell transfer, but reports no new findings.
January 2011 in “Leather Science and Engineering” This study found that rabbit skin histology revealed changes in collagen and elastic fibers after soaking, dehairing, and tanning processes, impacting fiber tightness and fur removal.
July 2026 in “Acta Biomaterialia” This study introduced a bioengineering platform that creates early-stage hair peg-like structures within tissue-engineered skin substitutes by integrating human keratinocytes and dermal papilla cells with laser-micropatterned collagen scaffolds, providing a foundation for future appendage-inclusive skin regeneration efforts.
18 citations
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February 2015 in “Acta Crystallographica Section D: Structural Biology” This study reports that Ca 2+ binding alters the dynamics and surface properties of PKD-like domains in Clostridium histolyticum collagenases, enhancing their stability and potentially aiding in collagen-targeting vehicle development.
169 citations
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June 2013 in “Medicine” This article reviews the structure and function of the skin and its importance for understanding skin diseases, without providing new clinical results.
77 citations
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May 2017 in “Medicine” This article reviews over 1000 skin diseases affecting patients' quality of life and highlights the importance of understanding skin biology and pathology, but provides no new results.
68 citations
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May 2009 in “Medicine” This article discusses the structure and function of the skin and its role in skin disease pathophysiology and reports no new research findings.
49 citations
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May 2021 in “Medicine” Understanding skin, hair, and nails is crucial due to their complexity and impact on health.
27 citations
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August 2016 This article discusses the importance of understanding the skin's structure and function for comprehending both healthy skin biology and skin disease pathophysiology, but reports no new findings.
12 citations
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September 2023 in “Polymers” This study reported that a newly developed hydrogel composed of recombinant type I collagen and chitosan, incorporating a metal–polyphenol structure, demonstrated strong mechanical and healing properties, effectively promoting wound healing in a full-thickness skin defect model.
2 citations
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May 2025 in “Medicine” This source underscores the importance of understanding skin structure and function to comprehend both healthy skin biology and skin disease pathophysiology, highlighting skin's extensive involvement in healthcare due to infections, drug reactions, and diseases like psoriasis.
November 2025 in “Journal of Investigative Dermatology” Dark skin has stronger barriers and structure due to specific gene activity.
In this study, autotransplanted interfollicular epidermis keratinocytes in a collagen dermis framework formed follicular-like structures, but their proliferation ceased after 15-20 days.
July 2026 in “Macromolecular Bioscience” In this study on wound healing, sulfated glycosaminoglycans from sturgeon cartilage enhanced fibroblast cell proliferation, migration, and collagen deposition, significantly accelerating wound closure and promoting re-epithelialization in both in vitro and in vivo tests.
52 citations
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March 2015 in “Tissue Engineering Part C Methods” This study presented 3D images of human dermis, revealing fewer elastic fibers near hair follicles compared to other regions, which may aid future skin engineering efforts.
8 citations
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November 2020 in “Skin Research and Technology” This study found that enlarged facial pores in women show distinct microstructural alterations, including regular keratinocyte arrangement and irregular dermo-epidermal junctions, highlighting changes in skin tension linked to pore enlargement.
4 citations
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November 2014 The skin protects the body, regulates temperature, senses touch, and makes vitamin D.
March 2026 in “Cosmetics” In this comprehensive review, researchers reported that macromolecules like type I collagen, keratin, and ceramides enhance hair health by improving follicular function and increasing hair density, strength, shine, and resilience, as shown in various in vitro, animal, and human studies.
September 2025 in “Sahel Journal of Life Sciences FUDMA” This study reported that albino Wistar rats exposed to chemical hair straighteners showed significant hair fiber damage and scalp skin deterioration, which worsened with repeated and prolonged application, highlighting the cytotoxic potential of these products and potential systemic risks.
September 2023 in “Clinical anatomy” This study examined the subcutaneous structures in forehead creases using cadavers and observed that dense fibrous structures connecting the dermis to the frontalis muscle, as well as specific epidermal and dermal characteristics, may contribute to the formation of these creases.
June 2026 in “Scientific Reports” This study found that systemic testosterone exposure in transgender individuals with XX genotype alters skin biology, increasing androgen and estrogen receptor-positive cells, collagen density, and fibronectin expression while reducing immune cells, which could affect surgical outcomes by promoting a male skin phenotype.