TLDR Understanding skin structure and function is crucial due to its role in health and prevalence of many skin diseases.
The document discussed the structure and function of the skin, highlighting its role as the largest organ of the human body composed of a multilayered stratified epidermis, hair follicles, sweat and sebaceous glands, and a dermis with collagen and elastic fibers. It emphasized the importance of understanding skin biology and pathophysiology due to the prevalence of over 1,000 skin diseases, which account for up to 20% of general practitioner referrals. Conditions like psoriasis, eczema, urticaria, and melanoma were noted for their significant impact on healthcare resources and patient quality of life.
143 citations
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September 2008 in “Experimental gerontology” Skin aging is due to impaired stem cell mobilization or fewer responsive stem cells.
418 citations
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September 2012 in “Nature” African spiny mice can regenerate skin, hair, and cartilage, but not muscle, and their unique abilities could be useful for regenerative medicine.
4 citations
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May 2005 in “Seminars in Plastic Surgery” Carlos Oscar Uebel developed a hair transplant method that looks natural, has low risk, and shows full growth in 6-12 months.
19 citations
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January 2007 in “Journal of medical investigation” GFP transgenic mice help study cell origins in skin grafts.
1039 citations
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February 2009 in “Nature Reviews Molecular Cell Biology” Skin stem cells are crucial for maintaining and repairing the skin and hair, using a complex mix of signals to do so.
2 citations
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April 2021 in “bioRxiv (Cold Spring Harbor Laboratory)” The conclusion is that analyzing RNA from skin oils is a promising way to understand skin diseases.