Development of Interfollicular Epidermis on the Surface of Collagen Framework of the Dermis in Experimental Animals

May 1992 in “ PubMed ”

Ostrovskiĭ Aa, Shatrova Vo

interfollicular epidermis keratinocytes collagen framework autotransplantation hair follicle bursas follicular-like structures

TLDR Keratinocytes grew and migrated into hair follicle areas but disappeared after 15-20 days.

The study investigated the behavior of interfollicular epidermis keratinocytes in an autotransplantation experiment using a collagen dermis framework prepared from a skin flap. The interfollicular epidermis was detached and transferred to the collagen framework, which was placed on a full-thickness skin defect. It was found that keratinocytes not only developed in this environment but also migrated into hair follicle bursas, forming follicular-like structures. These structures exhibited differentiation typical of interfollicular epidermis. However, despite some retention of proliferative ability, the ingrowth of cells disappeared by the 15th to 20th day post-transplantation.

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research Structure of Canine Skin

7 citations , March 1986 in “British Veterinary Journal”

Canine skin has two main layers: the epidermis and dermis, with a supportive subcutis layer.