Uncovering the Nanoscale Structure and Biophysics of Cutaneous Fibrosis: A Short Review

April 2024 in “ Authorea (Authorea) ”

Kehong Wang, Kehong Wang, Laura Forster, Xiaopeng Li, Jun Huang, Hansen Samuel S., Dimitris Menemenlis, Kexin He

TLDR Understanding the nanoscale structure of skin fibrosis can improve knowledge of wound healing and tissue regeneration.

This review discusses the nanoscale structure and biophysics of cutaneous fibrosis, highlighting the role of the extracellular matrix (ECM) and fibroblast activation in wound healing. Techniques such as Raman spectroscopy, nanoindentation (NI), atomic force microscopy (AFM), and small-angle X-ray scattering (SAXS) are emphasized for their ability to characterize collagen protein expression, local ECM biomechanics, and collagen ultrastructure. These methods can enhance our understanding of the biophysical interactions within the collagen fiber network, aiding in the comprehension of fibroblast behavior and the mechanisms underlying tissue regeneration and fibrosis.

View this study on authorea.com →

Discuss this study in the Community →

Related Community Posts Join

6 / 12 results

community Neck tension, and hair loss, I am 100 percent sure that there is a connection

in Treatment 19 upvotes 7 months ago

The user believes neck tension and poor posture contribute to hair loss, noticing improvements with yoga and muscle relaxation. Replies suggest androgenic alopecia as the cause and recommend exercises.

community A Different Take on Curing MBP

16 upvotes 5 years ago

Addressing hair loss by focusing on posture, blood flow, and craniofacial development. Methods include improving posture, cardiovascular activity, scalp massages, healthy diet, meditation, using minoxidil, and addressing craniofacial issues.

community How do you use rosemary oil and peppermint oil?

in Question 6 upvotes 4 years ago

Rosemary oil and peppermint oil may promote hair growth and increase cutaneous blood flow, showing promise as treatments for androgenetic alopecia. Minoxidil 2% is also used for treating hair loss.

community Scientific evidence for Peppermint & Rosemary oils + My Experience

in Research/Science 114 upvotes 2 years ago

Natural treatments for hair loss, specifically peppermint oil and rosemary oil; how they can be used as a supplementary or alternative treatment to pharmaceuticals such as finasteride and minoxidil; and the personal experience of the user Divallo, who has seen an increase in density and thickness after using these oils for around 2.5 years. The post also touches on the potential antifungal properties of the oils and their effects on cutaneous blood flow.

community high bloodpressure and crown thinning in early 20s

in Is this regrowth? 9 upvotes 6 months ago

A user with kidney disease and high blood pressure experienced hair thinning, especially around the vertex. They are currently using finasteride and oral minoxidil but are considering whether to resume blood pressure medication despite managing symptoms with diet and exercise.

community HMI-115 update: Chime Biologics and Hope Medicine Enter Manufacturing Agreement to Speed up the Launch of First-in-class Antibody Drug HMI-115 Targeting Endometriosis and Androgenic Alopecia

in Research/Science 112 upvotes 1 year ago

Chime Biologics and Hope Medicine are speeding up the launch of a first-in-class antibody drug, HMI-115, for endometriosis and androgenic alopecia. The treatment involves a series of subcutaneous injections, has shown promising results in phase 1, and continues to promote hair regrowth even after the treatment is stopped.

Similar Research

5 / 1000+ results

Fibroblast Heterogeneity and Functions: Insights from Single-Cell Sequencing in Wound Healing, Breast Cancer, Ovarian Cancer, and Melanoma

research Fibroblast Heterogeneity and Functions: Insights from Single-Cell Sequencing in Wound Healing, Breast Cancer, Ovarian Cancer, and Melanoma

March 2024 in “Frontiers in genetics”

Different types of fibroblasts play specific roles in wound healing and cancer, which could help improve treatments.

Early Dengue Virus Infection in Human Skin: A Cycle of Inflammation and Infectivity