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    GlossaryFibroblast Activity (fibroblast behavior)

    production of collagen and extracellular matrix by connective tissue cells

    Fibroblast activity refers to the behavior and function of fibroblasts, which are specialized cells in connective tissue that produce collagen and other extracellular matrix components. These cells play a crucial role in wound healing, tissue repair, and maintaining the structural integrity of tissues. Enhanced fibroblast activity can lead to improved skin health and hair growth, while impaired activity may contribute to conditions like scarring or alopecia.

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      learn Verteporfin

      chemical that might completely regrow follicles from hair transplant extractions

      learn Redensyl

      commercial product with a blend of mostly natural ingredients for hair regrowth

      learn SCUBE3

      a signaling molecule from dermal papilla cells being actively researched

      learn Melatonin

      hormone commonly taken for sleep aid has some topical benefits for hair

      learn Hydrocortisone

      a synthetic cortisol used for anti-inflammatory effects

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      community Verteporfin and Microneedling

      in Treatments 6 months ago
      Clinical studies by Dr. Barghouthi and Dr. Bloxham indicate that Verteporfin, when used with FUE and FUT hair transplantation methods, shows promise in hair follicle regeneration and minimal scarring due to its ability to inhibit Yes-associated protein (YAP). Microneedling at depths of 3-3.5mm, combined with Verteporfin, could potentially reactivate dormant follicles, although the optimal dosage and application method are still under investigation. Concerns remain about the DHT sensitivity of regenerated follicles, highlighting the need for further research to optimize trauma levels and Verteporfin concentrations to achieve effective and scar-free hair regeneration.

      community Looks like a real cure to the root of baldness (DHT-induced senescence) was proven earlier this year

      in Research/Science  743 upvotes 2 years ago
      A study that outlines the full model for androgenic alopecia (AGA) which links DHT to cellular senescence in dermal papilla cells, and suggests black chokeberry as a source of cyanidin 3-O-arabinoside polyphenol with potential anti-oxidant properties that could reverse this process. The post encourages reaching out to experts in anti-aging and longevity to research treatments involving the polyphenol.

      community This is the best time in human history to be fighting hair loss

      in Treatment  193 upvotes 2 years ago
      This conversation discusses the advancements in treatments for hair loss, including finasteride, dutasteride, minoxidil and new promising treatments such as pyrilutamide and verteporfin. Other treatments discussed were taking minoxidil orally, tretinoin to turn non-responders into responders and microneedling to further boost growth.

      community Does finasteride/dutasteride reverse aging?

      in Chat  45 upvotes 2 months ago
      Finasteride and dutasteride can improve skin texture and reduce acne by lowering DHT but do not reverse aging. They may enhance skin and hair health for some, but can also cause side effects like dry skin and sexual dysfunction.