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      More Than One Way to Skin

      research More than one way to skin . . .

      218 citations , April 2008 in “Genes & Development”
      This research discusses how epithelial stem cells in the skin maintain normal homeostasis, contribute to wound repair, and highlights the importance of these processes, as defects can lead to skin diseases including cancers, but provides no new experimental results.
      Penetration of Drugs Through Skin: A Complex Rate-Controlling Membrane

      research Penetration of drugs through skin, a complex rate-controlling membrane

      211 citations , June 2012
      This review discusses recent advances in skin penetration mechanisms, specifically focusing on the enhanced understanding of the follicular pathway and its implications for transdermal therapies, immune system targeting, and nanoparticle safety.
      Alopecia Areata: A Review of Disease Pathogenesis

      research Alopecia areata: a review of disease pathogenesis

      191 citations , May 2018 in “British journal of dermatology/British journal of dermatology, Supplement”
      This study reviewed recent theories on alopecia areata's pathogenesis, highlighting its autoimmune nature due to immune privilege disruption in hair follicles, and noted current treatments have limited efficacy with high relapse rates, underscoring the need for further research into its mechanisms for better therapies.
      Phenotypic Variation in Biotinidase Deficiency

      research Phenotypic variation in biotinidase deficiency

      184 citations , August 1983 in “˜The œjournal of pediatrics/˜The œJournal of pediatrics”
      In this study, biotinidase deficiency in children usually presented with neurological or skin symptoms, while metabolic ketoacidosis and organic aciduria appeared later.
      Treatment of Hirsutism With Spironolactone

      research Treatment of Hirsutism With Spironolactone

      183 citations , March 1982 in “JAMA”
      This study reported that spironolactone at 200 mg/day significantly improved facial hair growth in women with hirsutism and showed a sustained reduction in ovarian androgens over one year.
      Epidermal Stem Cell Diversity and Quiescence

      research Epidermal stem cell diversity and quiescence

      168 citations , August 2009 in “EMBO molecular medicine”
      This review discusses epidermal stem cell diversity, revealing previously unrecognized differences in stem cell populations, but reports no new experimental results; it highlights the need for further exploration of stem cell interactions and quiescence.
      Frontal Fibrosing Alopecia: A Review of 60 Cases

      research Frontal fibrosing alopecia: A review of 60 cases

      166 citations , April 2012 in “Journal of The American Academy of Dermatology”
      This study reviewed clinical data from 60 patients with frontal fibrosing alopecia and found increasing prevalence and generally poor response to treatment, with the cause remaining unclear.
      Epithelial Stem Cells And Implications For Wound Repair

      research Epithelial stem cells and implications for wound repair

      156 citations , October 2012 in “Seminars in Cell & Developmental Biology”
      This study found that hair follicle stem cells initially contribute to wound re-epithelialization, but long-lasting epidermal cells are primarily derived from a stem cell population in the isthmus portion of hair follicles.
      An Update on Congenital Adrenal Hyperplasia

      research An Update of Congenital Adrenal Hyperplasia

      151 citations , December 2004 in “Annals of the New York Academy of Sciences”
      This review discusses nonclassical 21-hydroxylase deficiency as the most common autosomal recessive disorder in humans and highlights the effectiveness of glucocorticoid treatment in reversing related symptoms.
      A Matter of Life and Death: Self-Renewal in Stem Cells

      research A matter of life and death: self‐renewal in stem cells

      150 citations , December 2012 in “EMBO Reports”
      This review explores the mechanisms of adult stem cell self-renewal, using skin as a model, and reports no new results but raises important unanswered questions in the field.
      The Immune Functions of Keratinocytes in Skin Wound Healing

      research The Immune Functions of Keratinocytes in Skin Wound Healing

      147 citations , November 2020 in “International Journal of Molecular Sciences”
      This review discusses the immune roles of keratinocytes in wound healing and chronic wound inflammation, emphasizing their potential impact on chronic wound pathology and highlighting areas for future research.
      K ATP Channels and Cardiovascular Disease

      research K ATP Channels and Cardiovascular Disease

      144 citations , March 2013 in “Circulation Research”
      This study reports that mutations in the SUR2 gene are linked to Cantu syndrome, highlighting the role of KATP channels in cardiovascular health and potential new therapies.
      Lupus Erythematosus: Systemic and Cutaneous Manifestations

      research Lupus erythematosus: systemic and cutaneous manifestations

      144 citations , September 2006 in “Clinics in Dermatology”
      This article outlines manifestations of systemic lupus erythematosus, noting rapid joint symptom improvement with corticosteroids and antimalarial drug responsiveness for skin symptoms, and links anti-Ro with photosensitive rash and subacute lupus.
      Human Skin Stem Cells and the Aging Process

      research Human skin stem cells and the ageing process

      143 citations , September 2008 in “Experimental gerontology”
      This review discusses the diverse roles and characteristics of epidermal and dermal stem cells in skin regeneration and aging, highlighting their potential applications in regenerative medicine and reports no new clinical results.
      Exosomes for Repair, Regeneration, and Rejuvenation

      research Exosomes for repair, regeneration and rejuvenation

      135 citations , December 2015 in “Expert Opinion on Biological Therapy”
      This review synthesizes recent research on exosomes, highlighting their role as key modulators in regenerative outcomes and suggesting they may offer advantages over stem cell-based therapies in process and regulation.
      Stem Cell Dynamics in the Hair Follicle Niche

      research Stem cell dynamics in the hair follicle niche

      135 citations , December 2013 in “Seminars in Cell & Developmental Biology”
      This review examines the literature on the molecular and cellular makeup of the hair follicle niche and how it influences stem cell behavior during hair regeneration, but does not provide new experimental results.
      Obesity and the Skin

      research Obesity and the skin

      128 citations , September 2011 in “British Journal of Dermatology”
      Obesity is linked to various skin problems and may increase the risk of skin cancer.