Search

everythingexperts & clinicslearnfaqsresearchcommunity

for

Search:↓

This review discusses the drug repurposing of cardiovascular medications like aspirin and statins for new uses, including potential anti-tumor effects, noting promising experimental outcomes but less conclusive clinical trials, particularly in the field of cancer treatment.

This review discusses recent advances in the therapeutic potential of exosomes for wound healing, highlighting their benefits and challenges but reports no new clinical results.

This review discusses the psychological importance of hair and explores how various hair cosmetics can affect hair health, emphasizing that certain products can lead to acute hair problems when repeatedly altering the natural style.

This study found that blue light at a wavelength of 453 nm promoted hair growth ex vivo, potentially through interacting with OPN3 receptors in human hair follicles.

This review discusses the role of keratins in maintaining epidermal structure and function and reports no new results; the authors emphasize the lack of rational therapies for skin disorders linked to keratin mutations.

In this study, Ganoderma lucidum extract was found to significantly inhibit 5alpha-reductase activity and testosterone-induced prostate growth in rats, suggesting potential use for treating benign prostatic hyperplasia.

This study found that securinine and ajmaline significantly inhibited hepatocellular carcinoma cell viability and induced apoptosis, with securinine showing lower toxicity to normal liver cells.

This review summarizes existing knowledge on androgen receptor activity in breast cancer and reports no new clinical findings, with emphasis on therapies targeting androgen signaling in specific BC subtypes.

This study found that in vivo, a novel microneedle system for valproic acid delivery may improve hair regrowth efficacy by upregulating hair follicle development pathways more effectively than topical application.

This study demonstrated that a c-Kit-CreER-driven mouse model confirms melanocyte stem cells as a genuine source of melanoma, paralleling human melanoma in heterogeneity and gene signatures.

Fibroblasts can be turned into melanocytes for potential skin treatments.

This review discusses the role of Toll-like receptors in wound healing and highlights their potential therapeutic value but notes that their role in human wound healing and chronic wounds is not well understood.

This study found that overexpression of Hoxc13 in GC13 mouse models affects hair follicle differentiation by interacting with medulla-specific genes, particularly Foxq1, suggesting a regulatory pathway for medulla differentiation.

This study identified 63 genetic loci associated with male-pattern baldness, uncovering genes and pathways that may help develop treatments and suggesting its connection to other human conditions.

In castrated rats, this study found that triterpenoids from Ganoderma lucidum inhibited both types of 5α-reductase and reduced prostate growth linked to testosterone but not dihydrotestosterone.

In this review, the researchers highlight LED therapy as an emerging and safe treatment for skin inflammatory conditions, aging, and hair growth disorders, noting its integration into dermatological practice but emphasizing the need for more controlled studies to confirm its efficacy.

This study found distinct gene expression profiles in alopecia areata-affected skin, suggesting T-cell mediated immune responses and unique gene profiles between different stages of the disease.

This study reviews recent advancements in microneedles made from PLGA, highlighting their use in delivering vaccines, drugs, and proteins through the skin with minimal invasiveness, and discusses the challenges and future potential of these delivery systems.

This article proposes a mechanistic model for how platelet-rich plasma therapy may stimulate hair growth in androgenetic alopecia by promoting vascularization and activating specific signaling pathways, but it reports no new experimental results.

This study observed that in aged mouse skin, there was an increase in IL-17-expressing T helper cells, γδ T cells, and innate lymphoid cells, and blocking IL-17 signaling reduced skin inflammation and delayed age-related changes, suggesting it as a potential target to mitigate skin aging.

This paper discusses the variability in COVID-19 susceptibility and severity, emphasizing factors like biological differences and suggesting potential precision medicine approaches, but it reports no new clinical results.

This study identified novel genetic associations with skin phenotypes such as age-spots, freckles, and hair characteristics in Japanese women, providing insights into the genetic basis of these traits.

This review discusses how androgens may regulate wound healing and inflammation, noting that testosterone appears to inhibit healing and promote inflammation, but it reports no new clinical results.

This article reviews methods to enhance epithelial–mesenchymal interactions for hair follicle bioengineering but does not present new experimental results; it emphasizes optimizing combinations for successful regeneration.

This study found that overexpression of the transcription factor Tcf3 accelerates keratinocyte migration and skin wound healing in mice, highlighting its potential as a therapeutic target for wound repair.

This study found that the JMJD3/NF-κB-Notch1 pathway plays a crucial role in regulating keratinocyte migration and skin wound healing, with Notch1 affecting key genes involved in cell migration.

The study found that severe insulin resistance and premature diabetes are common in patients with PCNT genetic defects, primarily affecting those over four years old, while not impacting early insulin signaling in adipocytes.

This study found that Brg1, a chromatin-remodeling enzyme, plays a critical role in hair regeneration and early epidermal repair by regulating bulge stem cells through a Brg1-Shh interaction.

This study suggests that the HDAC9 gene is a third susceptibility gene for male-pattern baldness, with significant associations found in both German and Australian samples.

This study found that the antiandrogen drug enzalutamide reduced TMPRSS2 levels and significantly decreased SARS-CoV-2 entry and infection in lung cells, supporting further clinical trials for COVID-19 treatment.