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This study found that hydroxycinnamate derivatives, especially a compound named 10a, effectively inhibited SRD5A1 activity and protein expression in cell assays, suggesting potential for treating androgen-related conditions.

This study found that deleting all three Tet genes in mice led to shorter hair shafts and altered hair types, with associated changes in gene expression and DNA hydroxymethylation.

The researchers reported that hair follicle germinative epidermal cells can form complex structures when associating with papilla cells in culture, unlike other types of epidermal cells.

This study introduced rPanglaoDB, an R package that facilitates the integration of public scRNA-seq datasets to effectively characterize rare cell types, exemplified by generating the first unbiased transcriptome profile of fibrocytes.

This study found that Sonic hedgehog signaling is crucial for Merkel cell development around hair follicles in mice, with Polycomb repressive complex 2 loss causing ectopic Merkel cells across all hair types.

In this study, a deep neural network model called regX was developed to prioritize driver regulators for cell state transitions by incorporating gene-level regulation and interactions, showing potential therapeutic targets in type 2 diabetes and hair follicle development when applied to single-cell multi-omics data.

This review highlights the potential of cell-free therapies, particularly cell extracts, in addressing radiation-induced salivary gland damage from head and neck cancer treatment, emphasizing their practicality and safety compared to traditional therapies despite incomplete understanding of their bioactive components.

This study indicates that COL17A1 plays a crucial role in the differentiation process of hair-follicle-associated pluripotent stem cells.

This review explores the potential of cell-mediated drug delivery systems in dermatology, highlighting their ability to target inflamed or diseased skin while discussing applications in diseases like atopic dermatitis and melanoma, along with challenges such as immunogenicity and manufacturing.

This study provides a comprehensive overview of human umbilical cord mesenchymal stem cell-derived extracellular vesicles (HUCMSC-EVs), suggesting their potential to combat aging and alleviate age-related disorders by rejuvenating multiple organs in animal models and discussing engineering strategies to harness their full anti-aging potential.

This study provides a detailed analysis of cell subpopulations in a mouse model of wound-induced hair follicle regeneration, revealing specific cellular dynamics and heterogeneity that may influence hair follicle neogenesis.

This review discusses factors affecting hair health, types of alopecia, and the potential of phytochemicals in managing hair loss but reports no new clinical results; it highlights the need for further studies.

This study found that pen-type microwells enhanced hair follicle germ formation by promoting cell assembly, suggesting microwell array geometry significantly influences in vitro hair follicle development.

This study found that hair-type tissues in hedgehogs show higher enrichment of immune-related genes compared to spine-type tissues, suggesting that spines evolved to protect against injuries and infections.

This review discusses various types of stem cells used in regenerative medicine, including adult stem cells and induced pluripotent stem cells (iPSCs), and evaluates them based on their embryonic tissue origins to explore new therapeutic approaches.

This study investigated single-cell changes in photoaged skin, revealing distinct cell clusters and increased activity in PD-L1 and PD-1 pathways in sun-exposed areas, enhancing understanding of UVA-induced skin damage and potential prevention targets for photoaging and UV-induced skin cancers.

In this study, researchers explored the molecular and cellular traits of avian reticulate scales, finding that they lack localized stem cell niches for regeneration, unlike other scale types, leading to repair but not regeneration after wounding.

This review explores how various skin cell types contribute to photoaging driven by UV radiation, detailing their interactions and molecular mechanisms like oxidative stress and ECM degradation, ultimately offering insights for future anti-photoaging strategies.

This article discusses various types of primary cicatricial alopecias and reports no new clinical results; it emphasizes the importance of accurate diagnosis for effective management.

This article reviews various types of alopecia, their diagnostic features, and patterns, but presents no new clinical findings; the authors discuss multiple mechanisms and classification challenges.

This study found that zebrafish with a mutation in the GDP-fucose biosynthesis gene exhibited enhanced and faster regeneration of mechanosensory hair cells, implicating the importance of this gene and Notch signalling regulation in hair cell regeneration mechanisms.

Systemic mastocytosis may cause a type of hair loss called cicatricial alopecia.

This article discusses various types of alopecia, their causes, and potential treatments, but it provides no new clinical results or studies.

This review discusses the regulatory roles of type 2 alarmin cytokines in skin immunity, focusing on their implications in host defense, chronic inflammation, and cancer, but reports no new clinical results.

This review examines the potential of adipose-derived stem cells in disease treatment and highlights the need for further research to clarify their effectiveness and safety.

This study found that the distribution of desmogleins is associated with specific types of keratinization and hair anchorage, as well as hypotrichosis.

In this study, researchers used single-cell RNA sequencing to map the hair follicle microenvironment in fine-wool sheep, identifying specific cell types and gene expressions that influence wool fiber diameter, with dermal papilla cells playing a significant role in hair follicle development.

This study mapped a detailed genetic profile of goat hair follicle apoptosis, identifying key genes and regulatory factors involved in the hair cycle, offering new insights into programmed cell death.

This study highlighted the effectiveness of HT-scCAT-seq as a tool for understanding gene regulation in single cells, offering insights into embryonic skin development and proposing a framework for exploring regulatory mechanisms in various biological and disease contexts.

This research found that hyaluronic acid increased cell proliferation and type I collagen more effectively than poly-L-lactic acid in both human fibroblast cultures and rat dermis.