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Hair follicle stem cells have significant potential for treating various disorders.

Lgr5 is a marker for active, long-lasting stem cells in mouse hair follicles.

This review summarizes fundamental concepts and recent advancements in hair follicle biology, including insights from mouse models into broader molecular and cellular processes relevant to regeneration and development.

This review discusses experimental data, technologies, and genetic factors related to stem cell niches, highlighting their role in tissue regeneration and diseases, but reports no new results.

This review synthesizes recent findings on the hair follicle stem cell niche and its complex interactions, exploring potential pathways for developing new hair growth therapies; it reports no new clinical results.

This review discusses how certain adult stem cells can produce factors that support the maintenance of other stem cell populations within shared niches, and it reports no new experimental results.

This study found that skin-resident Treg cells regulate hair follicle stem cell proliferation and differentiation through the Jag1-Notch signaling pathway, influencing hair regeneration.

This research describes mouse models to explore Kindlin-1's role in skin disorders, including Kindler syndrome, revealing novel integrin-independent pathways potentially leading to skin tumors.

In this study, the researchers observed that post-radiation hair follicle repair in 3D architecture occurs through independent, long-range cell movements along the basal surface, resembling 2D healing processes.

This review explores the diverse physiological roles of the vitamin D endocrine system, discussing current research on receptor structure, transcription details, murine models, and alternative receptors, but reports no new findings.

Mammalian organs regenerate using stem cells and cell plasticity, but this ability declines with age.

Skin stem cells maintain and repair the outer layer of skin, with some types being essential for healing wounds.

This review explores the diverse roles and heterogeneity of fibroblasts across different organs, highlighting their potential involvement in both normal tissue functioning and fibrotic diseases, but reports no new experimental results.

This review covers the connection between thyroid diseases and skin conditions like alopecia, dermatitis, and vitiligo, and highlights the need for further research on the role of thyroid hormones in skin health.

This review discusses recent progress in understanding the cellular mechanisms of sebaceous gland development and maintenance, emphasizing the role of stem and progenitor cells in related skin pathologies, and reports no new results.

This study reports that the novel small molecule IM176OUT05, by modifying stem cell metabolism, promoted hair regrowth and increased hair follicle numbers in mice.

This review discusses vitamin D and calcium signaling roles in epidermal stem cell processes essential for wound healing but reports no new experimental results, emphasizing their potential interdependent regulatory mechanisms.

This study found that deleting Snai2 and Snai3 genes in mice disrupts immune cell development, resulting in severe autoimmunity and early death due to the loss of immune tolerance.

This review discusses the role of phospholipases in skin and hair health, suggesting that understanding their molecular control could inform new treatments for related conditions, but it presents no new clinical results.

This review discusses the process and benefits of Platelet-Rich Plasma therapy for hair restoration, emphasizing its safety and potential for encouraging hair growth, but reports no new clinical results.

This study from PRP Bristol suggests that PRP therapy may stimulate hair growth by revitalizing dormant follicles, noting its rising popularity as a non-surgical option for hair restoration.

This study assesses the potential of exosomes as a therapeutic option for androgenetic alopecia, examining their mechanisms and effectiveness. The authors conducted a systematic review of existing research to explore how these extracellular vesicles might stimulate hair growth and restore follicle function.

This study found that using a commercially available IPL home-use device led to significant hair reduction and demonstrated long-term efficacy in maintaining hair reduction one year after treatment.

This review discusses the significant role of Wnt signaling in skin development, homeostasis, and disease, highlighting recent advances in understanding its diverse functions, but reports no new experimental results.

This review explores the mechanisms of adult stem cell self-renewal, using skin as a model, and reports no new results but raises important unanswered questions in the field.

This study found that activation of Wnt/β-catenin signaling in mouse testes promotes spermatogonial differentiation and reduces the stem cell pool, with SHISA6 inhibiting this process and maintaining stem cell characteristics.

This review examines the challenges of hair follicle regeneration and outlines strategies for bioengineering human hair follicle models, without presenting new experimental results.

In this study, Wnt-3a was found to play an important role in partially maintaining and expanding epithelial skin stem cells in vitro, suggesting potential for in vitro stem cell culture without feeder cells.

This study suggests that epithelial-derived Pop-Up Keratinocytes (ePUKs) may be a promising cell source for regenerative medicine due to their specific phenotypic traits and their influence on wound healing.

In this study, researchers discovered that activating TERT in mouse skin epithelium triggers dormant hair follicle stem cells, leading to rapid hair growth, through a pathway independent of telomere extension.