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This study reviews advancements in hair follicle regeneration, discussing the benefits and limitations of methods such as organ germ assembling, stem cell induction, and bioprinting, while highlighting the challenges of replicating embryonic signals and finding suitable cell sources for clinical applications.

Scientists found gene mutations that affect hair loss, skin stem cells, and skin disorders, and identified drugs that may help treat blood vessel and skin conditions.

This study characterized keratin-based biomaterials that self-assemble into hydrogels, demonstrating their potential to achieve hemostasis in a lethal liver injury model through specific biomaterial-receptor interactions.

In this study, keratin genes mHa1 and mHb4 were unable to form an extensive keratin network in one cell line, altering endogenous keratin distribution, but showed better integration in another cell line.

In this study, researchers developed a promising transdermal agent using Triton X-100-modified polyethyleneimine that successfully delivered genetic material to hair follicle cells in mice, potentially alleviating hair loss due to androgenetic alopecia by promoting cell proliferation and inhibiting apoptosis.

In this study, researchers developed an in vitro airway-organoid model using human lung-derived cell lines on RADA16-I hydrogels to serve as a potential tool for studying adenovirus isolation, pathogenesis, and antiviral drug screening.

This study found that metformin may promote hair follicle regeneration by enhancing dermal cell activity in an in vitro mouse model, suggesting potential for treating pattern hair loss.

This study found that human hair follicle dermal papilla cells and keratinocytes self-assembled differently in 3D spheroid co-cultures, providing insights into cell distribution and organogenesis during skin regeneration.

This study found that hyaluronic acid increased the size and cell proliferation of mixed aggregates in a 3D culture model, indicating its role in human hair follicle germ-like structure formation without enhancing dermal papilla cell markers.

This study developed a nanoscale biomimetic matrix that effectively and stably expands human hair follicle stem cells, offering a new tool for hair follicle reconstruction research.

This article reviews the regulation of gene expression and assembly of intermediate filaments but presents no new findings.

This review summarizes the current applications and mechanisms of self-assembled peptide hydrogels in promoting skin, bone, and nerve regeneration, highlighting their potential due to their biocompatibility and supportive role in tissue healing.

In this review, the researchers discussed the role of cell wall components and proteins in root hair growth, emphasizing the complex interplay of subcellular factors, and identified open questions and future research directions in root hair mechanobiology.

This study found that ILK deficiency disrupts hair follicle development by impairing cell polarity and laminin-511 assembly, but these defects can be partially reversed with exogenous laminin-511.

In this study, researchers demonstrated that human hair keratins can self-assemble into stable nanofibrous networks in vitro, which are compatible with human skin cells and useful for regenerative applications.

This perspective reviews enzyme-instructed self-assembly (EISA) as a conceptual framework for supramolecular chemical biology, emphasizing its innovative role in developing adaptive biomaterials and synthetic cellular machines without providing new experimental results.

In a murine model of androgenetic alopecia, this study found that the newly designed IGF-1 biomimetic peptide Ac-GFFY-IGF led to faster and superior hair regrowth compared to minoxidil, suggesting potential for improved human therapies.

In this study, keratin hydrogels derived from human hair were found to significantly enhance nerve regeneration in a mouse model, acting effectively as scaffolds by influencing Schwann cell behavior.

This review discusses how engineering cell surfaces with polyelectrolytes can address challenges in cell therapy and related biomedical fields and reports no new research findings.

This review discusses the unique properties, design, and fabrication of peptide hydrogels for biomedical applications, focusing on advances in drug delivery, gene therapy, and regenerative medicine; it reports no new clinical results.

This study found that incorporating PCL-based nanoscaffolds into liver spheroids enhances their viability and liver-specific biofunctionality, suggesting these scaffolds improve the model's potential for preclinical drug screening by increasing sensitivity to acetaminophen toxicity compared to traditional methods.

This study found that fibronectin is crucial for hair follicle stem cell function and regeneration, with its deletion impairing regeneration but restoration by dermal injection of exogenous fibronectin.

This review explores recent advancements in precise cell manipulation technologies, detailing the status, principles, benefits, limitations, and future potential of methods like single-cell manipulation and 3D bioprinting for cells and tissue engineering.

This research found that deleting the SLC3A2 gene in hair follicle stem cells disrupts their maintenance and proper differentiation, leading to hair follicle growth defects and altered skin regeneration through a YAP/Taz-dependent pathway.

In this study, peptide nanofiber gels RG and RJ significantly accelerated the healing of deep second-degree burn wounds in vivo, with greater wound closure rates and enhanced tissue regeneration compared to controls, attributed to increased angiogenesis and reduced systemic inflammation.

This study developed a mathematical model indicating that the amino acid sequences of intermediate filament proteins, rather than flexibility differences, significantly impact assembly rates.

This review discusses the history and development of keratin biomaterials for biomedical uses, highlighting their biological activity and biocompatibility, and provides no new research findings.

This study found that numerous genes involved in hair growth, including 73 co-up-regulated ones, were differentially expressed in goat hair follicles during the hair growth cycle.

This study found that keratin hydrogels extracted from human hair showed potential as biodegradable and biocompatible filler materials, promoting angiogenesis and cell proliferation in rat models.

This study found that keratin scaffolds derived from human hair promoted excellent cell viability and showed minimal inflammatory response and vascular integration when tested in in vitro and in vivo settings.