Search

everythingexperts & clinicslearnfaqsresearchcommunity

for

Search:↓

Enhancing regulatory T cells may help treat autoimmune diseases like alopecia areata.

CD8+ T cells re-expressing CD45RA may predict treatment resistance in severe alopecia areata.

This study reports that AhR pathway expression is significantly reduced in lymphocytes of alopecia areata patients, suggesting its potential as a diagnostic marker and therapeutic target.

In this study, Luan et al. showed that epidermal stem cells play a key role in wound healing by coordinating the recruitment of regulatory T cells and neutrophils, which help balance immune tolerance and inflammation.

This study found that for thyroid cancer patients who underwent radical mastectomy, the combination of CAF regimen and fufangbanmao capsule improved short-term clinical efficacy, enhanced immune function, reduced drug toxicity, and positively impacted quality of life compared to the CAF regimen alone.

In this case study, a 65-year-old male with hepatocellular carcinoma treated with the PD-1 inhibitor Sintilimab developed alopecia universalis alongside significant tumor regression and complete remission, highlighting a rare immune-related adverse event with effective anti-tumor outcomes.

This animal study observed that treatment with the S1PR modulator NXC736 significantly reduced lesion area and CD8+ T cell infiltration in mice with alopecia areata, suggesting its potential as a promising therapy for the condition.

In this study, the elimination of NG2+ hair follicle stem cells during the anagen phase was associated with an aggravated sensitization phase of allergic contact dermatitis, suggesting their immunosuppressive role.

This article discusses diffuse alopecia areata, highlighting its autoimmune characteristics, more intense inflammation, and challenges in diagnosis, but presents no new clinical findings.

This study found that RANKL signaling enhances CD8+ T cell-mediated anti-viral immunity during herpes simplex virus infection by preventing apoptosis of Langerhans cells, suggesting potential therapeutic applications.

Specific immune cells cause alopecia areata and blocking certain proteins can prevent it.

This case report documents the development of vitiligo-like lesions in a patient with autoimmune thyroiditis following the use of topical squaric acid dibutylester for alopecia.

This review discusses non-motor symptoms in autoimmune myasthenia gravis and associated thymomas, highlighting abnormal T-cell clones as a contributing factor, but reports no new clinical results.

IL-27 may help prevent hair loss by creating immune-suppressing cells.

This study identified key genes linked to immune cells and potential therapeutic compounds for alopecia areata by evaluating upregulated genes from patient datasets, highlighting T and NK cell involvement in hair follicle attack and suggesting drug candidates through molecular docking and dynamics simulations.

This study developed and analyzed a mathematical model for alopecia areata involving interactions among immune cells and cytokines, establishing conditions under which hairless patches can become stable and pervasive, particularly with certain biological rate levels and chemotactic sensitivities.

In this case report, mogamulizumab treatment for Sézary syndrome was associated with rashes and alopecia in a patient, highlighting the potential for immune-mediated side effects and suggesting that such adverse effects might indicate a favorable prognosis, though further studies are needed.

In this animal study, researchers discovered that CD4 T cells from mice with alopecia areata can induce the disease more efficiently than those from unaffected mice, likely by supporting CD8 T cell activation and hair follicle attack.

This review explores the role of Tregs in autoimmune skin diseases, transplantation, and skin cancer, and discusses Tregs-based therapies' potential for treating autoimmunity without reporting new experimental results.

This study found that fibroblast loss in the upper dermis from UVR exposure is linked to a deregulated inflammatory response, with T cells playing a protective role in fibroblast survival.

In this study, researchers identified unique prenatal lymphocyte features in human fetal skin, including proliferative naive T cells and memory-like T cells, which may influence antigen and allergen responses in utero and infancy.

This study found that anagen stage protein homogenates and specific epitopes from melanogenesis proteins activated CD8 T cells, suggesting alopecia areata is an anagen-specific disease.

This open-label study found that oral tofacitinib led to significant hair regrowth in patients with moderate-to-severe alopecia areata, supported by changes in gene expression and T cell dynamics.

This review discusses recent advances in understanding alopecia areata's disease mechanisms and highlights JAK molecules as promising therapeutic targets, but reports no new clinical results; controlled trials are needed.

This review discusses new insights into the pathogenesis of alopecia areata related to perifollicular immune and endocrine factors and potential new treatments, but it reports no clinical results.

This study suggests that human dermal Vδ1+ γδ T-cells may contribute to alopecia areata pathogenesis by targeting stressed scalp hair follicles and inducing immune privilege collapse.

This article describes a rare case of alopecia with both scarring and non-scarring features, combining histologic signs of central centrifugal cicatricial alopecia with select immunologic features of alopecia areata.

This letter discusses a case of Hepatitis C-related vitiligo in a patient with Ivemark syndrome and presents no new clinical results.

An 8-year-old girl developed a rare skin condition in a linear pattern on one side of her body after a lung infection, which improved with treatment.

This review discusses various factors influencing alopecia areata and explores newer therapeutic options like biologics and regenerative techniques, but it reports no new clinical trial results.