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research Sulforaphane, L-Menthol, and Dexpanthenol as a Novel Active Cosmetic Ingredient Composition for Relieving Hair Loss Symptoms
This study found that sulforaphane may help alleviate hair loss by increasing hair count after 18 weeks of use and enhancing the expression of a DHT-degrading enzyme in cellular models.
research [Two cases of the rare Cronkhite-Canada syndrome].
This study describes two Danish cases of Cronkhite-Canada syndrome presenting with malnutrition and gastrointestinal issues; both patients underwent successful treatment and remission after developing colonic adenocarcinomas.
research Solubility of Foreign Molecules in Stratum Corneum Brick and Mortar Structure
This study presents a method for directly measuring the solubility of solid chemicals in the skin's stratum corneum under various humidity conditions, emphasizing its importance for dermal drug delivery and chemical safety assessments.
research Protein-Losing Enteropathy, Anasarca and Dermatological Manifestations on People of Advanced Age: Don't Overlook the Diagnostic Hypothesis of a Cronkhite Canada Syndrome
This report discusses a late-onset case of Cronkhite-Canada syndrome that improved with prednisone treatment, highlighting the importance of early diagnosis to reduce life-threatening complications.
research Identification of SLC40A1, LCN2, CREB5, and SLC7A11 as ferroptosis-related biomarkers in alopecia areata through machine learning
This study identified four ferroptosis-related genes, SLC40A1, LCN2, CREB5, and SLC7A11, as potential diagnostic markers for alopecia areata, revealing reduced expression in affected patients compared to controls, with a predictive model showing high accuracy in differentiating the condition.
research Synthesis of porcine pCLCA2 protein during late differentiation of keratinocytes of epidermis and hair follicle inner root sheath
In this study, researchers found that the pCLCA2 protein is expressed in specific areas of pig skin, but its role in skin structure or function remains unclear.
research Anti-androgenetic effect of diphlorethohydroxycarmalol on testosterone-induced hair loss by inhibiting 5α-reductase and promoting Wnt/β-catenin signaling pathway in human dermal papilla cells
In this study, DPHC from the brown alga Ishige okamurae demonstrated potential to prevent androgenic alopecia by inhibiting hair loss and promoting hair growth through multiple cellular mechanisms.
research Conversion of Carotene to Vitamin A by Sebaceous Glands
In this study, carotene injected into the skin was converted into vitamin A by sebaceous gland cells, where it was not normally detectable.
research Dermal nanocrystals from medium soluble actives – Physical stability and stability affecting parameters
This study established a stable formulation for caffeine nanocrystals in specific solvent mixtures, which could be used to test their potential for enhanced hair follicle targeting and penetration.
research Use of silicon for skin and hair care: an approach of chemical forms available and efficacy
This review evaluates the scientific literature on silicon supplements, noting that orthosilicic acid shows higher bioavailability, but emphasizes the need for further clinical studies on safety and efficacy.
research Skipping of Exons by Premature Termination of Transcription and Alternative Splicing within Intron-5 of the Sheep SCF Gene: A Novel Splice Variant
This study identified a novel SCF mRNA splice variant in white merino sheep skin, which may play a role in hair follicle melanogenesis.
research Eficacia en alopecia de un acondicionador anticaída con Serenoa serrulata y tocoferol. Estudio piloto
This study aimed to evaluate the effectiveness of a hair conditioner containing Serenoa serrulata extract and tocoferol applied 3-4 times per week for 90 days against androgenic alopecia.
research A Phase 1 Study to Investigate the Effects of Cortexolone 17α‐Propionate, Also Known as Clascoterone, on the QT Interval Using the Meal Effect to Demonstrate ECG Assay Sensitivity
This phase 1 study reported that after administering supratherapeutic doses of cortexolone 17α‐propionate, a topical antiandrogen intended for hair loss treatment, there was no effect on the QTc interval, indicating no measurable cardiac safety concerns in the concentration range tested.
research Disturbed Keratinocyte Differentiation in Transgenic Mice and Organotypic Keratinocyte Cultures as a Result of Spermidine/Spermine N1-Acetyltransferase Overexpression
This research suggests that defects in keratinocyte differentiation due to putrescine accumulation in SSAT transgenic mice lead to skin changes and hair loss, and reducing putrescine can promote hair regrowth.
research KERION MICROSPORICUM WITH HEMATOGENOUS AND ECTOGENOUS MICROSPORIDS
This report describes a rare case of scalp kerion due to microsporosis in a Portuguese child, noting the unusual combination with other microsporid features and treatment details.
research Promotion of Skin Carcinogenesis by Dimethylarsinic Acid in Keratin (K6)/ODC Transgenic Mice
This study found that dimethylarsinic acid significantly accelerates skin tumor development in hair follicle-targeted K6/ODC transgenic mice.
research Screening the Chemical Composition and Bioactivity of Cerasus serrulata Flower Extracts Using Two Extraction Methods
This study found that Cerasus serrulata extracts, when obtained through specific methods, demonstrate significant antioxidative and antibacterial properties, as well as potential anti-alopecia effects in a mouse model, potentially making them useful supplements for these purposes.
research Inhibition of glycosphingolipid synthesis reverses skin inflammation and hair loss in ApoE−/− mice fed western diet
In this study, a high-fat, high-cholesterol diet in atherosclerotic mice led to skin inflammation and hair problems, which could be reversed by inhibiting glycosphingolipid synthesis.
research A Convenient Synthesis of (16S,20S)-3β-Hydroxy-5α-pregnane-20,16-carbolactam and Its N-alkyl Derivatives
This paper describes the synthesis of (16S,20S)-3β-hydroxy-5α-pregnane-20,16-carbolactam from tigogenin without presenting new experimental results.
research Avaliação in vitro da segurança e eficácia de nutracêutico à base de alecrim para a pele de cães
This study found that the nutraceutical product DERM decreased the pro-inflammatory cytokine IL-6 in mesenchymal stem cells under in vitro conditions.
research Targeted expression of spermidine/spermine N1-acetyltransferase increases susceptibility to chemically induced skin carcinogenesis
This study suggests that activation of polyamine catabolism in K6-SSAT transgenic mice may significantly increase skin tumor development and progression to carcinomas following chemical induction.
research In vivo microautoradiography of [3H]1,24(OH)2D3 (tacalcitol) following topical application to normal rats and in vitro metabolism in human keratinocytes
This study found that after topical application in rats, 1,24-dihydroxyvitamin D3 absorbed through both the stratum corneum and hair follicles, with about 30% excreted via the faeces.
research Atypical necrobiosis lipoidica of the face
This case report details a 36-year-old man with atypical necrobiosis lipoidica on his face, characterized by annular lesions and prominent giant cells without clear granuloma formation.
research Ceramide synthase 4 is involved in the regulation of hair follicle stem cell homeostasis
research Arachidonate 12-Lipoxygenase Inhibitors Promote S100A3 Citrullination in Cultured SW480 Cells and Isolated Hair Follicles
This study found that inhibiting arachidonate 12-lipoxygenase (ALOX12) may enhance hair cuticle maturation by increasing S100A3 protein citrullination and promoting cuticular differentiation in isolated human hair follicles.
research Modulating metal-organic frameworks by surface engineering of stearic acid modification for follicular drug delivery and enhanced hair growth promotion
In this study, metal-organic frameworks modified with stearic acid were used to deliver cardamonin to hair follicles, significantly promoting hair growth and cell proliferation in testosterone-challenged mice, suggesting potential benefits for androgenic alopecia treatment.
research PERAN SUPLEMENTASI VITAMIN D PADA TATA LAKSANA SARKOIDOSIS KUTIS
In this study, researchers highlighted that in sarcoidosis, macrophages in granulomas can produce vitamin D, potentially leading to calcium imbalances, where vitamin D supplementation may cause hypercalcemia, necessitating careful laboratory assessment before supplementation.
research A functional study of a case of glucagonoma exhibiting typical glucagonoma syndrome
In this case study, a man with necrolytic migratory erythema and a glucagonoma experienced decreased plasma glucagon levels and reduced metastases after treatment with dimethyltriazenoimidazole carboxamide.
research Optimization of Nanostructured Lipid Carriers (NLC) Extract Crude Fucoidan Algae Brown (Sargassum chrysanthemum): Design and Characterization
This study aimed to enhance the skin penetration of brown algae fucoidan using a Nanostructured Lipid Carrier, achieving a formulation with good physical quality and stability.