Two Cases of the Rare Cronkhite-Canada Syndrome

Cronkhite-Canada syndrome (CCS) is a rare, non-heritable condition marked by gastrointestinal polyposis, dysgeusia, malnutrition, total alopecia, and onychodystrophia. Two Danish patients (an 88-year-old female and a 69-year-old male) exhibited symptoms including malnutrition, dyspepsia, vomiting, dysgeusia, and hair loss. Upper endoscopy showed significant stomach oedema and polyposis. Both patients developed colonic adenocarcinomas, which were surgically removed. Treatment with hyperalimentation, prednisolone, and azathioprine led to remission in both patients, with the first patient achieving total remission.