TLDR A new, efficient method was developed to synthesize a specific compound and its derivatives.
The document described a concise synthesis method for (16S,20S)-3β-hydroxy-5α-pregnane-20,16-carbolactam starting from tigogenin. The most efficient route involved opening the lactone ring with an aminoalane reagent, followed by oxidation using PDC or Dess-Martin. The resulting oxo-amide was then cyclized using Et3SiH/TFA or Et3SiH/Bi(TfO)3. Alternatively, the lactone was converted to an oxo-acid and underwent microwave-assisted reductive amination. N-Alkyl derivatives were synthesized using a similar approach.
19 citations
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January 2016 in “Annals of Dermatology” Dutasteride is safe and effective for treating hair loss, but may decrease libido.
23 citations
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February 2010 in “European Journal of Medicinal Chemistry” 
211 citations
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November 1990 in “The Journal of Steroid Biochemistry and Molecular Biology” Finasteride effectively treats BPH, but needs more trials to understand potential.
19 citations
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July 2005 in “Steroids” Testosterone increases 3α-androstanediol levels, which can be blocked by finasteride.
131 citations
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September 2017 in “Molecular and Cellular Endocrinology” The document concludes that blocking the internal pathways that create androgens might help treat cancers that depend on sex hormones.
13 citations
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June 2006 in “Brain Research” Allopregnanolone likely doesn't influence ethanol's rewarding effects in these mice.
January 1983 in “Elsevier eBooks” Masculinization in affected individuals occurs gradually after puberty due to hormone changes.
186 citations
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December 2011 in “Molecules” Three specific 4-azasteroid-2-oximes showed strong enzyme inhibition, but less than finasteride.
