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research A Convenient Synthesis of (16S,20S)-3β-Hydroxy-5α-pregnane-20,16-carbolactam and Its N-alkyl Derivatives

2 citations , May 2020 in “Molecules”

This paper describes the synthesis of (16S,20S)-3β-hydroxy-5α-pregnane-20,16-carbolactam from tigogenin without presenting new experimental results.

research Synthesis of Finasteride,5α-reductase inhibitors

January 2003 in “Natural Science Journal of Xiangtan University”

In this study, researchers improved the synthesis process for finasteride, reducing impurity levels and making it suitable for industrial production.

research Synthesis of 5α-Reductase Special inhibitor Finasteride

January 2009 in “Journal of Xingtai University”

This article describes the synthesis process of Finasteride from 3β-Hydroxypregn-5-en-20-one using a series of chemical reactions, including dehydrogenation and iodination.

research Pharmacovigilance in Pediatric Patients with Epilepsy Using Antiepileptic Drugs

8 citations , April 2022 in “International Journal of Environmental Research and Public Health”

This study found that pediatric epilepsy patients on polytherapy experienced more adverse drug reactions compared to those on monotherapy, despite improved seizure control with polytherapy.

research External genitalia abnormalities in male rats exposed in utero to finasteride, a 5α-reductase inhibitor

122 citations , July 1990 in “Teratology”

This study found that oral administration of finasteride to pregnant rats caused dosage-related developmental toxicities, including hypospadias and decreased anogenital distance in male offspring.

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community 22 | ~34 Months Finasteride Update

820 upvotes 2 years ago

A user shared their 34-month update on using finasteride for hair loss, noting they maintained regrowth even after stopping minoxidil a year ago. Other users shared similar experiences and expressed admiration for the results.

community DHT reduction in the scalp for all doses of dutasteride is now available.

in Finasteride/Dutasteride 357 upvotes 1 year ago

Higher doses of dutasteride reduce scalp DHT more effectively than finasteride, but have diminishing returns after 3mg daily and may cause more side effects. Combining dutasteride with topical minoxidil can enhance results, but using both finasteride and dutasteride together is unnecessary.

community Minimizing systemic DHT reduction with topicals

5 upvotes 3 weeks ago

The conversation discusses minimizing systemic DHT reduction using topical treatments for hair loss, specifically mentioning Minoxidil, Finasteride, and a proprietary carrier for DUT by XYON Health. The focus is on finding effective DHT blockers with minimal systemic absorption.

community Is this insufficient reduction of DHT while being on fin for 5 years?

5 months ago

Finasteride helps with hair loss by lowering DHT levels in the scalp, which is more important than blood DHT levels. If finasteride is not effective, consulting a doctor or considering switching to dutasteride may be advisable.

community 5 alpha reductase type 1 is in brain tissue producing the main endogenous gabaergic allopregnanolone, not 2. How can finasteride as a 5ar2 lower that?

27 upvotes 1 year ago

Finasteride and dutasteride are discussed for hair loss, with concerns about their effects on neurosteroids and potential side effects like depression. Alternatives like topical estrogen and lifestyle changes are considered, with varying opinions on mental health and hair regrowth.

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