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This study found that carvone, a plant-derived compound, decreases melanin content and inhibits melanoma cell proliferation through the cAMP pathway, suggesting potential benefits for treating melanomas and other hyperpigmentation disorders.

This study found that adenosine promotes hair growth by stimulating the Wnt/β-catenin pathway in cultured human dermal papilla cells through activation of the adenosine receptor.

This study found that puerarin, derived from Pueraria thunbergiana, may stimulate melanogenesis and prevent follicular depigmentation in a hair graying mouse model.

This study found that tribuloside, a flavonoid from Tribulus terrestris L., enhances melanin production in human melanocytes, zebrafish, and human skin samples without causing toxicity, potentially through inhibiting PDE to increase cAMP levels and promote the melanin biosynthesis pathway.

This study suggests that the NGF/TrkA/CREB system plays a crucial role in promoting outer root sheath cell proliferation in cashmere goats, which may aid in marker-assisted breeding.

This study found that using a palmitoylated peptide, Pal-MPAPO, delivered through hydrogel microneedles effectively promoted hair regrowth in mice with efficacy comparable to minoxidil, while requiring less frequent application.

This study demonstrated that α-phellandrene promotes dermal papilla cell proliferation through a cAMP-mediated pathway and upregulates VEGF expression, suggesting its potential use in hair loss prevention.

This review discusses the role of corticotropin-releasing hormone in human skin, focusing on its regulation, receptors, and functions, and highlights parallels with the hypothalamo-pituitary-adrenal axis; it reports no new research findings.

This study found that thyroid-stimulating hormone receptors are functionally expressed in various skin cells, implying potential physiological and pathological roles in skin, especially in conditions like autoimmune diseases.

Human hair follicles have a unique metabolism that changes between growth stages and may contribute to baldness.

This review examines cell senescence pathways in melanocytes, highlighting the involvement of telomere attrition, the p16/RB pathway, and cAMP signaling in the context of melanoma development, but reports no new findings.

This review examines PAK4 signaling pathways in prostate cancer, Parkinson's disease, and melanogenesis, focusing on the potential role of the PAK4-CREB axis, without reporting new clinical results.

In this study on mice, intensive stress through methods like resiniferatoxin injections and physical restraint was found to inhibit hair follicle growth, with the mechanism involving the sympathetic nervous system and the cAMP signaling pathway in hair follicle stem cells.

This study found that C. japonicum flower extract significantly increased melanin content and cellular activity in human melanocytes and may improve follicular depigmentation and vitiligo through cAMP signaling.

This study found that corticotropin-releasing factor influences cytokine expression related to hair growth in human dermal papilla cells and suggests CRF receptor antagonists could be potential treatments for stress-induced hair loss.

Alpha-MSH affects mitochondrial function, and MC1R mutations may increase skin aging.

This study suggests that typical skin lesions in Carney complex may originate from the pro-melanogenic activity of a specific dermal fibroblast population influenced by PKA signaling.

This study indicates that CD4 protein may have a functional role in basal cell-like keratinocytes through TCR/CD3-independent signaling, affecting their proliferation, differentiation, and migration.

This study found that TGFbeta is a key pathway causing age-related loss of dermal fat's antimicrobial function, suggesting that targeting TGFBR might help restore skin defense against infections in older age.

The researchers reported that adenosine increases FGF-7 expression in dermal papilla cells, which may stimulate hair growth via the A2b adenosine receptor and cAMP pathway.

This study found that, despite confirming MC1R expression and functional cAMP signalling, α-MSH treatment did not alleviate UVA-induced stress in adult dermal fibroblasts, suggesting that α-MSH-MC1R may not directly protect against UVA-induced photoaging in these cells.

In this study, researchers analyzed the skin proteome of Alpine Merino sheep to identify proteins and pathways related to wool fiber diameter, finding that cyclic adenosine monophosphate and certain signaling pathways may play a role in this trait.

This study found that transfecting alpaca melanocytes with miR-5110 altered gene expression related to pigmentation, specifically identifying pathways like MAPK and Wnt as involved in melanogenesis regulation, providing insights into miR-5110's role in pigmentation processes.

This study suggests that cold atmospheric microwave plasma treatment may promote hair renewal by activating β-catenin and YAP/TAZ signaling in human dermal papilla cells.

This study found that Wnt3a increased beta-catenin signaling and upregulated specific genes in cultured human dermal papilla cells, enhancing their response to PGE2 and potentially aiding hair growth.

The researchers observed that normal murine hair follicles are direct targets for melatonin, with receptor expression varying throughout the hair cycle, suggesting melatonin's role in hair cycle control.

This study examined genetic adaptations in Tibetan sheep through whole-genome resequencing, identifying key genes related to hypoxia tolerance, wool color, and body size. These findings provide a foundation for future molecular breeding strategies to enhance wool quality and adaptive traits in these high-altitude environments.

In this study, α-MSH and cyclic AMP were found to stimulate melanogenesis in hair follicle cultures, while cyclic GMP and melatonin inhibited melanin production but not tyrosinase activity.

In this review, the authors discuss caffeine's potential mechanisms and benefits as a hair loss treatment, noting its possible effectiveness and safety, though they caution that existing studies often have significant design flaws.

This study found that p2y5 functions as a novel LPA receptor involved in the G13-Rho signaling pathway, with implications for human hair growth, and proposes renaming it to LPA6.