Whole-Genome Resequencing to Investigate the Genetic Diversity and the Molecular Basis Underlying Key Economic Traits in Indigenous Sheep Breeds Adapted to Hypoxic Environments

July 2025 in “ Frontiers in Veterinary Science ”

Dehong Tian, Buying Han, Xue Li, Quanbang Pei, Bai‐Cheng Zhou, Kai Zhao

hair follicle development HOX homeobox genes cAMP signaling melanogenesis MC1R

Studysummary This study examined genetic adaptations in Tibetan sheep through whole-genome resequencing, identifying key genes related to hypoxia tolerance, wool color, and body size. These findings provide a foundation for future molecular breeding strategies to enhance wool quality and adaptive traits in these high-altitude environments.

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