Novel circRNAs From Cashmere Goats: Discovery, Integrated Regulatory Network, and Their Putative Roles in the Regeneration and Growth of Secondary Hair Follicles

June 2022 in “ Czech Journal of Animal Science ”

Jincheng Shen, Yanru Wang, Man Bai, Yixing Fan, Zeying Wang, Wenlin Bai

circular RNAs circRNAs anagen telogen Wnt signaling pathway TGF-beta signaling pathway mTOR signaling pathway MAPK signaling pathway axon guidance secondary hair follicles SHFs hair growth phase hair resting phase

Studysummary This study identified 21 novel circular RNAs in cashmere goats, with nine significantly more expressed during the anagen phase of hair follicle growth, suggesting roles in hair regeneration and cashmere yield enhancement. Our plain-language summary of this paper — not a Tressless recommendation.

The study identified 21 novel circular RNAs (circRNAs) from the skin tissue of cashmere goats, with nine showing significantly higher expression in anagen skin tissue compared to telogen. These upregulated circRNAs were associated with key signalling pathways, including Wnt, TGF-beta, mTOR, MAPK, and axon guidance, suggesting their involvement in the regeneration and growth of secondary hair follicles (SHFs) in cashmere goats. The findings provided insights into the molecular mechanisms underlying SHF regeneration and growth, which could be crucial for enhancing cashmere production.

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