15 citations
,
August 2014 in “Journal of dermatological science” This study found that puerarin, derived from Pueraria thunbergiana, may stimulate melanogenesis and prevent follicular depigmentation in a hair graying mouse model.
21 citations
,
December 2023 in “Journal of Investigative Dermatology” This study highlights multiple factors contributing to hair graying, such as oxidative damage, melanocyte changes, and genetic influences, and suggests that repigmentation may be temporarily reversible, offering potential targets for future treatments while urging caution when applying mouse model findings to humans.
June 2025 in “Clinical and Experimental Dermatology” In this case report, a 25-year-old woman with alopecia areata experienced hair regrowth after treatment with baricitinib, despite not responding to conventional treatments, with the new hair initially appearing dark brown.
1 citations
,
January 2014 in “Indian journal of dermatology, venereology, and leprology” Papular mucinosis can cause eyebrow hair loss, but treatment can lead to regrowth.
January 2019 in “Journal of the American Leather Chemists Association” This study observed that processing techniques such as degreasing, bating, and tanning influence mink skin by altering the distribution of fat glands and collagen fibers, potentially impacting hair follicle structure and mink product quality.
July 2024 in “Applied Sciences” This study found that bimatoprost was significantly more effective than sweet almond oil in increasing eyebrow hair density and length in young women over a 5-week period.
26 citations
,
January 2018 in “Annals of dermatology/Annals of Dermatology” This review examines current understanding of hair graying and suggests it may be caused by depletion of melanocyte stem cells due to genotoxic stress or dysfunctional melanocytes from oxidative stress.
2 citations
,
October 2024 in “Journal of Cosmetic Dermatology” This study highlights that chemicals used in brow lamination, like ammonium thioglycolate and thioglycolic acid, may cause skin irritation and other systemic issues, suggesting a need for further investigation and regulatory measures.
April 2016 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that Sox2 and BMP signaling may be key regulators of pigmentation and melanocyte migration, as suggested by experiments in mice, human biopsies, and cell co-cultures.
46 citations
,
April 2014 in “PLOS ONE” This study found that compromised antioxidant activity in gray hair follicles affects both mature melanocytes and their immature precursors, linked to down-regulation of melanogenesis-related genes.
47 citations
,
January 2013 in “Indian Journal of Dermatology, Venereology and Leprology” This review examines the pathogenesis of premature hair graying and potential treatment avenues, but reports no new experimental outcomes, highlighting ongoing research challenges and hopes for drug development.
8 citations
,
March 2005 in “JDDG Journal der Deutschen Dermatologischen Gesellschaft” This case report describes a patient with glaucoma who developed reversible hyperpigmentation and hypertrichosis after using bimatoprost eye drops, aiming to explore prostaglandin analogues' potential roles in hair and depigmentation therapies.
22 citations
,
April 2013 in “Dermatologic surgery” In this study, daily application of bimatoprost 0.03% ophthalmic solution for 9 months significantly improved eyebrow appearance in individuals with mild to moderate eyebrow hypotrichosis, without observed side effects.
13 citations
,
September 2017 in “Oncotarget” This study suggests that increased Wnt signaling may cause melanocyte stem cell exhaustion, leading to hair graying in aged mice by promoting excessive differentiation of melanocytes.
56 citations
,
December 2010 in “The journal of investigative dermatology/Journal of investigative dermatology” This study suggests that the susceptibility of hair follicle melanocytes to oxidative stress as they age may be key in the graying of hair due to reduced catalase expression and activity.
This study found that ponytails with small fractions of gray hair have significantly lower swing height and higher damping, affecting the dynamic movement and appearance compared to those with fewer gray hairs.
1 citations
,
January 1999 in “Proceedings of the British Society of Animal Science” This research investigates apoptosis and bcl 2 expression in hair follicles cultured with and without biotin, but it reports no new results.
October 2022 in “Hair Transplantation” This article discusses the complexities of brow hair restoration and reports no new clinical results, emphasizing the meticulous and technically demanding nature of this procedure.
3 citations
,
July 2020 in “Mechanisms of Development” 44 citations
,
April 1979 in “Journal of Ultrastructure Research”
This study found that the dark pigmentation pattern in Dun Mongolian horses' "Bider marking" is closely associated with higher protein levels and specific localization of MITF and WNT3A, suggesting these are key factors in its formation.
January 2022 in “SSRN Electronic Journal” This study reports that aging in mice leads to curved hair follicles and an increase in white hairs, potentially due to changes in keratinocyte and melanocyte stem cells.
66 citations
,
June 1997 in “The Laryngoscope” This article discusses advancements in managing the aging brow and forehead, reporting on a tailored problem-specific approach using both innovative technologies and traditional surgeries, but provides no new clinical results.
9 citations
,
December 2010 in “Journal of The European Academy of Dermatology and Venereology” This letter reports repigmentation of hair in patients receiving latanoprost therapy.
November 2025 in “Journal of Investigative Dermatology” This study found that UVB exposure led to visible tanning and distinct DNA methylation changes in pigmentation genes in tan-capable skin but not in non-tan skin, highlighting GNAS as a potentially UVB-responsive gene.
18 citations
,
March 2015 in “Journal of Investigative Dermatology” In this study, silencing BMAL1 and PER1 genes increased melanogenic activity in follicular and epidermal melanocytes, suggesting that peripheral circadian clocks may regulate melanin pigmentation.
40 citations
,
November 2005 in “The journal of investigative dermatology/Journal of investigative dermatology” This study suggests that different melanocyte subpopulations in hair follicles have varying patterns of apoptosis and survival during the catagen phase, which may inform models for modulating melanocyte behavior in vivo.
15 citations
,
January 2017 in “Pigment International” This article reviews the pathogenesis and treatment approaches for premature graying of hair, noting the unsatisfactory options currently available, and reports no new clinical findings.
11 citations
,
January 2016 in “Evidence-based Complementary and Alternative Medicine” This study found that rice bran ash extract and orthosilicic acid both increased melanin synthesis and related protein expression in melanocytes, suggesting potential therapeutic use for melanin deficiency.
September 2023 in “Cells tissues organs” In this study, researchers observed that in mice, as they age beyond 200 days, unusual curved hair follicles and increased white hairs emerge, indicating stem cell-related changes in keratinocyte and melanocyte characteristics, providing insights into hair aging processes.