Changes in Characteristics of Murine Hair Follicles and Tissue Stem Cells Throughout Life
January 2022
in “
SSRN Electronic Journal
”
Studysummary This study reports that aging in mice leads to curved hair follicles and an increase in white hairs, potentially due to changes in keratinocyte and melanocyte stem cells.
Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer
The study investigates the aging-related changes in murine hair follicles (HFs) and tissue stem cells throughout the mouse's lifetime. By postnatal day 200 (P200), skin maturation is complete, and aging begins, marked by the appearance of curved HFs and hypopigmented hair bulbs, leading to increased white hairs. Keratin 15-positive keratinocyte stem cells stabilize in the hair bulge, supporting hair regeneration, while the low number of tyrosinase-related protein 2-positive melanocyte stem cells may contribute to aging characteristics in both melanocytes and keratinocytes. These findings offer insights into the mechanisms of hair regeneration and age-related hair changes in humans.
