Search

everythingexperts & clinicslearnfaqsresearchcommunity

for

Search:↓

This article highlights the importance of recognizing, preventing, and reporting adverse drug reactions to the FDA's MedWatch program, but does not present new research findings.

This study found that cortexolone 17α-propionate showed strong topical antiandrogenic activity, outperforming progesterone and several known antiandrogens, but lacked systemic antiandrogenic effects in animal models.

In this study, high-dose oral administration of Ramania leaf ethanol extract in Wistar rats resulted in no significant acute toxicity symptoms, though gastric ulcers and hair loss were observed. The extract is classified as non-toxic under specified guidelines, with an LD50 greater than 5000 mg/kg.

This study found that diphlorethohydroxycarmalol significantly increased prostaglandin $E_2$ synthesis in HaCaT human keratinocytes by upregulating COX-1 and COX-2 expression, suggesting potential benefits from elevated $PGE_2$ production.

In this study, three hair tonic formulas containing Kayu Secang extracts demonstrated hair growth activity in rabbits, with the chloroform-methanol fraction showing the most significant results.

This study found that telogen effluvium occurred in two subjects taking 500 mg of mefloquine weekly, and gastrointestinal intolerance was observed at higher doses in additional acute studies.

This review discusses the adverse effects of hair care products, highlighting irritation dermatitis and allergic contact eczema due to common allergens like paraphenylenediamine and glycerol monothioglycolate, but reports no clinical results.

This study found that anionic HSES achieved high complexation efficiencies with various steroids, significantly enhancing their solubility, while specific β-cyclodextrin thioethers showed selective binding to testosterone and estradiol.

Different medications can cause serious side effects in some people.

In this study, researchers synthesized the fictional compound 1-hydroxyindole and discovered its potential medical applications, including anti-aging properties, itch relief for atopic dermatitis, and as a stronger treatment for dementia compared to cilostazol. Additionally, they found that 1-methoxyindole derivatives function as anticancer agents in diets.

This study found that compound 3, a tetrahydropyridoindole carboxymethylated at position 5, significantly inhibited sorbitol accumulation in both rat eye lenses and tissues affected by diabetes, indicating its potential as a lead compound for ALR2 inhibition.

This review discusses the potential use of spin traps in cosmetic products to limit reactive oxygen species generated by pollution, emphasizing the need for further research due to toxicity and regulatory concerns.

In this study, treatment with DPCP alone was more effective for hair regrowth and presented fewer side effects in chronic extensive alopecia areata compared to combination therapy with DPCP and anthralin.

This study found that the dissolution profiles of different finasteride polymorphs may affect the quality of finasteride capsules, highlighting the need for polymorphic quality control.

This study reported that para-phenylenediamine and toluene-2,5-diamine are the main sensitizers in hair dye-related allergic contact dermatitis, with significant cross-reactivity to several other compounds.

In this study, researchers found that steroidal 17β-carboxamides 1-4 significantly inhibited 5α-reductase enzyme activity and reduced prostate weight more effectively than finasteride in a hamster model, without toxic side effects, suggesting potential for treating benign prostatic hyperplasia.

This study found that multiple treatment regimens for refractory hypertension were effective in controlling blood pressure in most patients, with diazoxide being the most effective but least tolerable option.

This study found that flavonoids with two hydroxyl groups in their B-ring, such as sterubin and luteolin, supported the regeneration of pigmented hair after skin injury, unlike those with one hydroxyl group.

This study suggests that specific structural features of minoxidil analogs, such as hydrophobic and hydrogen bond field contributions, are key to enhancing lysyl hydroxylase inhibitory activity, which could inform future hair growth treatments.

This study identified that the pruning woods from Juniperus phoenicea and Juniperus thurifera could serve as renewable sources of bioactive natural products, with compounds like cedrol showing potent antitick and antifungal activities.

This study identified a fungal sulfotransferase enzyme, FgSULT1, from *Fusarium graminearum*, expanding the sulfotransferase superfamily and offering new biocatalytic methods for producing bioactive sulfates.

In this study, phenylthiocarbamide intake was associated with hair graying in rats, while switching to tap water led some rats to regain their original fur color, suggesting dietary factors influence pigmentation.

This study evaluated a hair tonic formulated from oil palm leaf extract, finding it demonstrated very strong antioxidant activity and could prevent hair decolorization from sun exposure, with effective concentrations ranging from 25 to 200 ppm.

This study found that procyanidin oligomers bind to keratin and inhibit oxidative hair damage, suggesting their potential use in protective hair care products.

This literature review identified that phosphodiesterase 5 inhibitors, such as Tadalafil, are highly effective in improving lower urinary tract symptoms associated with benign prostatic hyperplasia, while the efficacy of saw palmetto remains inconsistent.

This study found that the compound 9,11-dehydrocortexolone 17alpha-butyrate (CB-03-04) showed strong local antiandrogenic activity in animal models, suggesting potential for treating prostate conditions.