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Fzd2 is important for skin and hair development through various signaling ways.

Hair loss in Androgenetic alopecia (AGA) is due to altered cell sensitivity to hormones, not increased hormone levels. Hair growth periods shorten over time, causing hair to become thinner and shorter. This is linked to miscommunication between cell pathways in hair follicles. There's also a change in gene expression related to blood vessels and cell growth in balding hair follicles. The exact molecular causes of AGA are still unclear.

Transplanted rat hair follicles grew hair and had increased but not fully restored nerve connections in mice.

Thyroid hormones affect skin texture, hair and nail growth, and can cause skin diseases related to thyroid problems.

Alopecia areata is an autoimmune disease causing patchy hair loss, often with other autoimmune disorders, but its exact causes are unknown.

Higher doses of cranial irradiation are linked to permanent hair loss.

Skin's uneven surface and hair follicles affect its stress and strain but don't change its overall strength, and help prevent the skin from peeling apart.

Removing centrosomes from skin cells leads to thinner skin and stops hair growth, but does not greatly affect skin cell differentiation.

Hair follicles in mutant mice self-organize into ordered patterns within a week.

Some cancer treatments can cause permanent hair loss.

Eating a high-fat fish oil diet caused mice to lose hair due to a specific immune cell activity in the skin linked to a protein called E-FABP.

The WNT signaling pathway is important in many diseases and targeting it could offer new treatments.

Beta-caryophyllene helps improve wound healing in mice, especially in females.

RANK is a key target in breast cancer treatment due to its role in tumor growth and bone metastasis.

Wnt signaling is important for development and cell regulation but can cause diseases like cancer when not working properly.

A form of vitamin E promotes hair growth by activating a specific skin pathway.

Using neurohormones to control keratin can lead to new skin disease treatments.

Norepinephrine helps skin cells grow, which is important for hair growth.

Beta-caryophyllene, found in essential oils, helps wounds heal better in multiple ways.

Regulating cell death in hair follicles can help prevent hair loss and promote hair growth.

Neurohormones help control skin health and could treat skin disorders.

The paper concludes that understanding melanocyte development can help in insights into skin diseases and melanoma diversity.

Certain proteins, Lgr5 and Lgr6, are important markers of adult stem cells and are involved in tissue repair and cancer development.

TGF-β is crucial for tissue repair and can cause diseases if not properly regulated.

Melatonin may benefit skin health and could be a promising treatment in dermatology.

ATP-dependent chromatin-remodeling complexes are crucial for gene regulation, cell differentiation, and organ development in mammals.

Stem cell niches support, regulate, and coordinate stem cell functions.

TGF-β is crucial for controlling stem cell behavior and changes in its signaling can lead to diseases like cancer.

Different types of stem cells and their environments are key to skin repair and maintenance.

The document concludes that adult mammalian skin contains multiple stem cell populations with specific markers, important for understanding skin regeneration and related conditions.