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Women with Polycystic Ovary Syndrome (PCOS) have lower levels of a substance called DIAPH1 in their blood, which is linked to changes in sugar metabolism and insulin resistance.

Pumpkin seed products may help improve prostate and bladder health by blocking certain enzymes and hormone receptors.

Sex hormones' effects on COVID-19 are unclear and more research is needed to understand their potential as treatment.

Androgens can cause hair growth in some areas but hair loss on the scalp.

Antiandrogens like flutamide are effective in treating conditions like prostate cancer and hair loss, but there's a need for more potent versions. Understanding their structure can help develop better treatments.

Male hormones affect COVID-19 severity and certain drugs targeting these hormones could help reduce the risk.

Natural 5AR inhibitors effectively improve mild to moderate hair loss in men.

Plant extracts effectively reduce hair loss and increase growth, offering a safe alternative treatment.

The document concludes that combination therapy is most effective for treating excessive hair growth in women with idiopathic hirsutism, and more research is needed to understand the condition.

Androgens, like DHT, affect hair growth and treatments like finasteride may help.

Prostate cancer cells can make their own androgens to activate the androgen receptor, and treatments like abiraterone may increase this ability, suggesting new therapies should target the entire steroid-making pathway.

Myo-inositol supplements may improve insulin sensitivity and help with conditions like PCOS and gestational diabetes, but more research is needed.

Finasteride effectively blocks enzyme causing male pattern baldness.

Finasteride effectively inhibits 5α reductase, while plant extracts like Permixon and Bazoton don't show significant results.

New compounds were made that block an enzyme linked to breast cancer better than existing treatments.

Inhibiting 5α-reductase can help reduce prostate cancer risk and improve treatment.

Four-amino acid part makes enzyme sensitive to finasteride.

A49T gene variant linked to higher prostate cancer risk, lower hormone levels, and slightly reduced balding risk.

Finasteride helps treat hair loss and prostate enlargement by blocking a specific enzyme.

Mice with human gene experienced hair loss when treated with DHT.

New steroidal compounds could be effective for treating conditions related to 5α-reductase enzyme activity.

Male hormones, or androgens, affect women's health in areas like mood and bone density, and hormone replacement therapy using antiandrogenic progestogens can improve mood disorders and alertness in menopausal women.

Finasteride affects urinary steroid profiles and can potentially hide steroid abuse in sports drug testing.

PNU157706 reduced rat sperm movement and fertility without affecting offspring health.

Finasteride treatment changes brain steroid levels and receptors, affecting brain function even after stopping treatment.

Some herbs show promise as antiandrogenic agents.

Finasteride irreversibly affects human steroid 5α-reductase 2, providing insight into its catalytic mechanism and disease-related mutations.

The document concludes that managing hirsutism involves identifying the cause, using a scoring system for severity, combining cosmetic and medical treatments, encouraging weight loss, and providing psychological support, while noting the need for more research on drug treatments.

Herbal alternatives like saw palmetto and green tea may offer safe, effective treatment for hormonal hair loss.

Finasteride inhibits enzyme activity in rhesus macaques, suggesting they're useful for evaluating similar drugs.