179 citations,
July 2016 in “Nature Reviews Molecular Cell Biology” Epigenetic changes control how adult stem cells work and can lead to diseases like cancer if they go wrong.
153 citations,
March 2017 in “Endocrine” Male pattern baldness involves genetics, hormones, and needs better treatments.
64 citations,
March 2005 in “Journal of Investigative Dermatology” Brain-Derived Neurotrophic Factor (BDNF) slows down hair growth and promotes hair follicle regression.
29 citations,
July 2014 in “PloS one” Meis1 is crucial for skin health and tumor development.
20 citations,
September 2013 in “Anti-Cancer Drugs” PTH-CBD could help prevent and treat hair loss caused by chemotherapy in mice.
14 citations,
February 2014 in “Experimental Cell Research” The conclusion is that teeth, hair, and claws have similar stem cell niches, which are important for growth and repair, and more research is needed on their regulation and potential markers.
9 citations,
July 2020 in “Experimental Dermatology” Topical L-thyroxine may help with wound healing and hair growth but should be used short-term due to potential risks.
2 citations,
July 2021 in “Biochemical and Biophysical Research Communications” CTHRC1 helps hair grow back, and plantar dermis mixture boosts it.
June 2021 in “Research Square (Research Square)” The exact identity of skin stem cells and how skin cells differentiate is not fully known.
Skin stem cells are crucial for maintaining and repairing skin, with potential for treating skin disorders and improving wound healing.
Wound healing is complex and requires more research to enhance treatment methods.
January 1989 in “Side effects of drugs annual” Some cancer and immune system drugs can cause serious side effects, including heart, lung, nerve, and organ damage, which need careful monitoring and management.
49 citations,
November 2021 in “Annual review of pathology” Lysophospholipids like LPA and S1P are important for hair growth, immune responses, and vascular development, and could be targeted for treating diseases.
11 citations,
March 2020 in “The journal of investigative dermatology/Journal of investigative dermatology” A specific group of skin stem cells was found to help maintain hair follicle cells.
6 citations,
October 2020 in “Frontiers in cell and developmental biology” WWOX deficiency in mice causes skin and fat tissue problems due to disrupted cell survival signals.
April 2024 in “Biomolecules” Exosomal miRNAs from stem cells can help improve skin health and delay aging.
3 citations,
December 2022 in “Cells” Cannabinoids like CBD and THC may help treat non-cancer skin diseases, but more research is needed.
56 citations,
February 2006 in “American journal of physiology. Cell physiology” Steroid sex hormones activate matriptase in prostate cancer cells but not in breast cancer cells.
11 citations,
January 2007 in “Veterinary dermatology” Fulvestrant at 10 mg/kg does not promote hair regrowth in dogs with alopecia X.
41 citations,
June 2006 in “Journal of Investigative Dermatology” Beard and scalp hair cells have different gene expressions, which may affect beard growth characteristics.
1 citations,
February 2021 in “Scholars international journal of anatomy and physiology” Different forms of FGF5 either promote or inhibit hair growth.
109 citations,
December 1998 in “The Journal of Dermatology” Manipulating the catagen and telogen phases of hair growth could lead to treatments for hair disorders.
94 citations,
June 2016 in “The FASEB Journal” The Wnt/β-catenin pathway helps tissue regeneration but can also cause fibrosis, and drugs that inhibit this pathway may aid in healing skin and heart tissues.
23 citations,
June 2012 in “PLOS ONE” KLF4 is important for maintaining skin stem cells and helps heal wounds.
9 citations,
July 2014 in “Experimental Dermatology” PTHRP agonists can stimulate hair growth, especially in damaged follicles, while antagonists may initially increase growth but ultimately inhibit it.
305 citations,
March 2018 in “International journal of molecular sciences” The document concludes that the understanding of scar formation is incomplete and current prevention and treatment for hypertrophic scars and keloids are not fully effective.
224 citations,
March 2006 in “Seminars in Cutaneous Medicine and Surgery” The document concludes that understanding hair follicle biology can lead to better hair loss treatments.
174 citations,
November 2002 in “Expert Reviews in Molecular Medicine” Hair loss needs more research for better treatments.
52 citations,
April 2013 in “Developmental Cell” Brg1 is crucial for hair growth and skin repair by maintaining stem cells and promoting regeneration.
February 2024 in “Frontiers in physiology” Modifying certain signals in the body can help wounds heal without scars and regrow hair.