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This study found that the uptake of molecules by hair is influenced by both hydrophobic and ionic charge interactions, with binding affinity decreasing as pH approaches the solute's dissociation constant.

This study demonstrated that dyeing can enhance the absorption coefficient of hair follicle tissues for selective photodestruction within human skin and hair follicles.

This study demonstrated that urea significantly accelerates the diffusion of poly(ethylene imine) into bleached human hair by increasing the diffusion coefficient twofold.

This study found that cationic lipid-based formulations enhanced the delivery of large molecules into hair follicles in human scalp skin, with potential to reach pharmacologically active concentrations in the hair bulb.

This study extended a skin diffusion model to include a porous pathway, effectively explaining the permeability of both polar and lipophilic solutes through the stratum corneum.

This review highlights the need for methodologies to understand and quantify drug penetration into hair follicles as significant drug pathways, noting this area lacks comprehensive articles and reports no new results.

This study demonstrated that vitamin B12 may promote hair growth in vitro by modulating intracellular signaling in the wnt-pathway, suggesting potential benefits for micrograft transplantation.

This study found various ABC transporters are transcribed in human hair follicles, suggesting their possible role in HF biology and potential for new therapeutic interventions.

This study found that applying benzyl nicotinate on open hair follicles led to a significant increase in blood flow, highlighting the role of the follicular pathway in epidermal penetration.

This article reviews potential applications and challenges of using the transfollicular route for drug delivery but does not present new clinical findings; it calls for further exploration and development in this field.

In this study, FITC-labeled BSA nanocarriers delivered a model drug deeper into porcine ear skin hair follicles than the carriers themselves, as shown by confocal microscopy.

This study confirmed the porcine ear skin model's effectiveness for studying nanoparticle-based drug delivery in human hair follicles, noting particle-dependent uptake and enhancement by massage.

This study's simulation found that Ascorbyl Tetraisopalmitate penetrates more efficiently through the skin's stratum corneum than via the infundibulum, following different pathways and dynamics in each membrane.

In this study, the authors found that applying hypobaric pressure to the skin significantly increases the transdermal permeation of large molecules by enhancing diffusion, despite the associated skin stretching and hair follicle enlargement not fully explaining this effect.

This study found that paracellular transport significantly contributes to the intestinal permeability of minoxidil, suggesting its limited suitability as a Biopharmaceutics Classification System reference drug due to potential variability.

Targeting drugs to hair follicles can treat skin conditions, but reaching deep follicle areas is hard and needs more research.

Transfollicular drug delivery can improve medication absorption through hair follicles.

This study found that drug delivery through human scalp skin may be more effective for lipophilic and hydrophilic drugs compared to abdominal skin, highlighting the potential of intrafollicular delivery methods.

This study found that the cyanoacrylate biopsy method could effectively evaluate drug distribution in hair follicles, suggesting its potential utility for assessing topically applied chemicals targeting hair follicles.

This study found that electroosmotic flow through hair follicles significantly contributes to solution flow during iontophoresis in hairless mouse skin.

This study found that targeting the hair follicle can be increased by using lipophilic drugs combined with surfactant solutions and propylene glycol.

This study found that Finasteride may spontaneously diffuse into an SDS-based model cell membrane at a significant rate, with distinct behavior in polar and non-polar solutions.

This study found that fermentation products from Bacillus sp. TC5 can effectively promote hair regrowth and improve transdermal drug absorption, suggesting their potential as eco-friendly agents in developing cosmeceuticals for hair restoration and skin repair.

This study introduces an efficient ghost-cell based immersed boundary method for simulating fluid-particle mass transfer, capable of accurately handling mixed boundary conditions at particle surfaces.

In this in silico study, researchers found that the hair follicle's contribution to dermal permeability of small molecules varies with the lipophilic and hydrophilic properties of substances, highlighting the need for careful characterization of substances filling the follicular route when interpreting experimental permeability data.

This study found that after topical application in rats, 1,24-dihydroxyvitamin D3 absorbed through both the stratum corneum and hair follicles, with about 30% excreted via the faeces.

This study found that rhodamine B penetrated human hair fibers more effectively from an aqueous solution compared to a methanol/ethanol solvent, with penetration depending on hair morphology.