Multi-Targeted Synergy of Bacillus sp. TC5 Fermentation Products for Transdermal Drug Delivery and Hair Regeneration

    January 2026 in “ Journal of Advanced Research ”
    Dan Liu, YiDan Chen, WenZhao Li … HaiLun He
    Studysummary This study found that fermentation products from Bacillus sp. TC5 can effectively promote hair regrowth and improve transdermal drug absorption, suggesting their potential as eco-friendly agents in developing cosmeceuticals for hair restoration and skin repair.
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    Research cited in this study 9

    1. Androgenetic Alopecia: Therapy Update Drugs · 2023
    2. Cooperation of TGF-β and FGF Signalling Pathways in Skin Development Cell Proliferation · 2023
    3. Minoxidil: A Comprehensive Review Journal of Dermatological Treatment · 2021
    4. The Peptide AC 2 Isolated from Bacillus-Treated Trapa Japonica Fruit Extract Rescues DHT-Treated Human Dermal Papilla Cells and Mediates mTORC1 Signaling for Autophagy and Apoptosis Suppression Scientific reports · 2019
    5. Bacillus/Trapa Japonica Fruit Extract Ferment Filtrate Enhances Human Hair Follicle Dermal Papilla Cell Proliferation via the Akt/ERK/GSK-3β Signaling Pathway BMC Complementary and Alternative Medicine · 2019
    6. A Role for the TGF-β/BMP Co-Receptor Endoglin in the Molecular Oscillator That Regulates the Hair Follicle Cycle Journal of Molecular Cell Biology · 2018
    7. In Vivo Hair Growth Promotion Effects of Ultra-High Molecular Weight Poly-γ-Glutamic Acid from Bacillus Subtilis (Chungkookjang) Journal of Microbiology and Biotechnology · 2015
    8. Exogenous IGF-1 Promotes Hair Growth by Stimulating Cell Proliferation and Downregulating TGF-β1 in C57BL/6 Mice In Vivo Growth Hormone & IGF Research · 2014
    9. A Short Peptide GPIGS Promotes Proliferation of Hair Bulb Keratinocytes and Accelerates Hair Regrowth in Mice Biological & Pharmaceutical Bulletin · 2005