Kinetics and Equilibrium of Solute Diffusion into Human Hair

July 2012 in “ Annals of biomedical engineering ”

Liming Wang, Longjian Chen, Lujia Han, Guoping Lian

polyphenol hydrophobicity ionic charge pH levels diffusion coefficient molecular size binding affinity solute dissociation hair-water partition coefficient adsorption properties

Studysummary This study found that the uptake of molecules by hair is influenced by both hydrophobic and ionic charge interactions, with binding affinity decreasing as pH approaches the solute's dissociation constant.

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The study explored how five polyphenol molecules are absorbed by human hair, revealing that the uptake is influenced by the molecules' hydrophobicity and ionic charge, and decreases with higher pH levels. A theoretical model was developed to analyze the data, which indicated that the effective diffusion coefficient of solutes is affected by molecular size, binding affinity, and solute dissociation. The research proposed quantitative-structure-property-relationships (QSPR) models that successfully predicted the hair-water partition coefficient and the effective diffusion coefficient, suggesting that these models could be useful for understanding the adsorption properties of various materials. The study's findings are significant for the field of cosmetic science, particularly in the formulation of hair care products, but the number of hair samples used was not mentioned.

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