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Mice without the vitamin D receptor have bone issues and other health problems, suggesting vitamin D is important for preventing various diseases in humans.

Male hormones may play a role in the development of heart disease, and more research is needed to understand their effects.

Melatonin affects many body functions beyond sleep by interacting with specific receptors in various tissues.

Coumarin derivatives show promise as anti-estrogenic agents for treating breast cancer, with some in clinical trials.

Calreticulin has roles in healing, immune response, and disease beyond its known functions in the endoplasmic reticulum.

Mutations in the SRD5A3 gene cause a new type of glycosylation disorder by blocking the production of a molecule necessary for protein glycosylation.

Antiandrogens like flutamide are effective in treating conditions like prostate cancer and hair loss, but there's a need for more potent versions. Understanding their structure can help develop better treatments.

Pectin biosynthesis is essential for the growth of cotton fibers and Arabidopsis root hairs.

The document concludes that Catalyst software is effective for drug design, identifying potent compounds for various medical conditions.

Too much androgen can cause hair loss; finasteride may help.

Eating less sugar, milk, and saturated fats and more vegetables and fish may help treat and prevent acne.

Finasteride treats enlarged prostate and hair loss, but may cause side effects in some patients.

The conclusion is that PCOS is caused by ovarian sensitivity to hormones and disrupted hormone control, possibly due to ovarian factors, and more research is needed.

New targets for making and using brain-synthesized steroids could lead to better treatments for brain disorders and alcoholism.

Estrogens help reduce skin aging, and SERMs might offer similar benefits without the risks of hormone therapy.

Hormones, especially androgens, play a big role in acne, but most acne sufferers don't have a hormone disorder. Hormonal treatments, including birth control pills, can be very effective for women whose acne doesn't improve with regular treatments.

Lignans and neolignans from plants may help protect against various health issues, including cancer and heart disease.

Skin surface lipids are important for skin health and altering them could help prevent aging and treat skin conditions.

The document concludes that certain genetic mutations and dietary factors are involved in acne development, and treatments like isotretinoin and diet changes can help manage it.

Cholesterol sulfate buildup due to a genetic mutation disrupts the skin barrier, leading to the scaling skin seen in X-linked ichthyosis.

The conclusion is that managing androgen excess requires long-term treatment, including hormonal contraceptives and androgen blockers, with follow-up after six months.

The document concludes that accurate measurement of serum androgens is crucial for diagnosing hyperandrogenism.

Mushrooms have beneficial properties for skin and hair care products and have great potential for future cosmetic use.

Acne is a chronic disease linked to various systemic conditions and has significant psychological and social effects.

PCOS affects women's health by increasing the risk of diabetes, heart disease, and reproductive issues.

Advanced hydrogel systems with therapeutic agents could greatly improve acute and chronic wound treatment.

Anti-acne medications may work by reducing the activity of a protein involved in acne development.

Certain fungi and bacteria help orchid seeds germinate and plants grow better.

Polycystic Ovary Syndrome is linked to higher risk of hypertension and heart disease.

Testosterone may slow down wound healing and increase inflammation.