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This study found that normal murine hair follicles are direct targets for melatonin bioregulation, expressing receptors that are regulated in a hair cycle-dependent manner, influencing keratinocyte apoptosis.

This study found that both 5-ALA and Photofrin can effectively destroy human microvascular endothelial cells in vitro and cause tissue necrosis in vivo, with Photofrin showing greater efficacy at lower concentrations or power densities.

This review highlights that bicalutamide, a non-steroidal antiandrogen used in prostate cancer treatment, is mainly effective through its (R)-enantiomer and emphasizes the need to monitor its adverse effects despite its targeted antiandrogenic action.

This review discusses the mechanisms and potential therapeutic benefits of mesenchymal stromal cell-derived extracellular vesicles delivered via biomaterials, but reports no new clinical results.

This review synthesizes recent research on exosomes, highlighting their role as key modulators in regenerative outcomes and suggesting they may offer advantages over stem cell-based therapies in process and regulation.

In this study, oral zinc sulphate was found to cause hair hypopigmentation and significantly inhibit eumelanogenesis in mice.

This review examines nanozymes as promising tools for cancer diagnosis and therapy due to their enzyme-mimicking catalytic properties and highlights their challenges, including biosafety and clinical translation, alongside potential improvements through biomimetic designs, particularly utilizing exosome-based strategies for targeted delivery to tumors.

This publication overview describes the Biomedical Journal of Scientific & Technical Research's rigorous peer review process and their focus on genetic, biomedical, and technical knowledge research within an open access format, but does not report specific study results.

This review explores the potential, challenges, and recent advancements of dissolving microneedles in drug delivery, summarizing their varied applications and current limitations without providing new clinical results.

This article discusses the potential benefits of GcMAF and oral MAF, developed by "Saisei Mirai", for cancer and other conditions, but reports no new clinical results.

This article reviews the benefits of herbal cosmetics over synthetic products, highlighting fewer side effects and improved skin and hair health, but presents no new clinical findings.

This study reports that finasteride administered orally in humans is mainly metabolized through oxidative pathways, with most of the dose excreted as metabolites, primarily in the feces.

This study found that using human hair follicle dermal papilla cells, 53BP1 focus counting can estimate radiation doses from 50 mGy after 5 hours, and focus size analysis refines dose estimation for doses ≥ 500 mGy up to 96 hours.

This phase II trial found that BI 2536 demonstrated limited antitumor activity across five solid tumor types, with no confirmed objective responses observed.

This study found that finasteride was rapidly absorbed and extensively metabolized in dogs, with most metabolites excreted in feces, and suggests that higher doses might saturate the metabolism mechanism.

This study found that the cyanoacrylate biopsy method could effectively evaluate drug distribution in hair follicles, suggesting its potential utility for assessing topically applied chemicals targeting hair follicles.

This study introduces MicrobeFDT, a tool that clusters chemically similar compounds and links them to gut microbial enzymes and toxicities, demonstrating its utility by uncovering previously unknown metabolism of the cancer drug altretamine.

This study found that enzyme activity related to cancer induction by polycyclic aromatic hydrocarbons can be increased by using a shampoo containing crude coal tar and significantly inhibited by imidazole compounds in human hair follicles.

In this study, heifers exposed to thyroid irradiation up to 30 Gy showed changes in thyroid hormone levels but tended toward recovery, without affecting immunity or productivity.

This study developed and tested Bicalutamide-loaded lipid vesicles in dissolving microarray patches for topical application, finding that they effectively deliver Bicalutamide through murine skin while maintaining a favorable safety profile, suggesting potential to improve treatments for androgenetic alopecia.

This study found that aged tritiated thymidine breaks down and incorporates into cytoplasmic macromolecules, not DNA, suggesting caution in its use.

This review provides an overview of biotin's role in metabolism and the consequences of deficiency but reports no new clinical findings; it highlights that intestinal bacteria usually meet biotin needs.

This study identified specific profiles and courses of adverse events associated with boron neutron capture therapy for head and neck cancer, suggesting differences based on the beam incidence site.

This study observed dynamic behaviors such as cluster formation, migration, and active proliferation of transplanted bone marrow cells in a mouse model, providing insight into cellular-level changes post-transplantation.

This paper details a method for measuring testosterone metabolism into seven androgens using digital autoradiography, which offers high sensitivity and reduces the need for radioactive materials.

In this study, novel mutations in the BTD gene were identified in a patient with profound biotinidase deficiency, highlighting the importance of biotinidase activity measurement and mutation analysis for early diagnosis.

This study found that targeting the hair follicle can be increased by using lipophilic drugs combined with surfactant solutions and propylene glycol.

This study observed that sonidegib led to a meaningful clinical response in a real-world Chinese cohort with locally advanced basal cell carcinoma, although pathological biopsy remains essential to confirm tumor clearance due to false positives in noninvasive assessments.

This study found that injectable finasteride microspheres provided a sustained drug release with a minimal initial burst in albino rabbits compared to oral suspension.

This study found that FLASH radiation within a Spread-out Bragg Peak retained its normal tissue-sparing effect compared to conventional radiation, with a 40% reduction in acute skin damage and an 18% reduction in fibrotic development in mice.