Disposition and Metabolism of Finasteride in Dogs

January 1997 in “ PubMed ”

Josephine R. Carlin, Philip Christofalo, Byron H. Arison, RE Ellsworth, Avery Rosegay, R. J. Miller, Shuet-Hing Lee Chiu, William J. A. VandenHeuvel

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Research cited in this study

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Mechanism-Based Inhibition of Human Steroid 5α-Reductase by Finasteride: Enzyme-Catalyzed Formation of NADP-Dihydrofinasteride, a Potent Bisubstrate Analog Inhibitor

research Mechanism-Based Inhibition of Human Steroid 5α-Reductase by Finasteride: Enzyme-Catalyzed Formation of NADP-Dihydrofinasteride, a Potent Bisubstrate Analog Inhibitor

136 citations , March 1996 in “Journal of the American Chemical Society”

Finasteride effectively blocks enzyme causing male pattern baldness.

research Identification of Human Cytochrome P450 Isozymes Responsible for the In Vitro Oxidative Metabolism of Finasteride

20 citations , October 1995 in “PubMed”

research In Vitro Biotransformation of Finasteride in Rat Hepatic Microsomes: Isolation and Characterization of Metabolites

5 citations , January 1994 in “PubMed”

research Finasteride: A Slow-Binding 5-Alpha-Reductase Inhibitor

70 citations , June 1993 in “Biochemistry”

Finasteride slowly binds to 5-alpha-reductase, affecting enzyme stability and inhibitor potency.

research Disposition and Pharmacokinetics of [14C]Finasteride After Oral Administration in Humans

17 citations , March 1992 in “PubMed”