Disposition and Metabolism of Finasteride in Dogs

    January 1997 in “ PubMed ”
    Josephine R. Carlin, Philip Christofalo, Byron H. Arison … William J. A. VandenHeuvel
    Studysummary This study found that finasteride was rapidly absorbed and extensively metabolized in dogs, with most metabolites excreted in feces, and suggests that higher doses might saturate the metabolism mechanism.
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    Research cited in this study 5

    1. Mechanism-Based Inhibition of Human Steroid 5α-Reductase by Finasteride: Enzyme-Catalyzed Formation of NADP-Dihydrofinasteride, a Potent Bisubstrate Analog Inhibitor Journal of the American Chemical Society · 1996
    2. Identification of Human Cytochrome P450 Isozymes Responsible for the In Vitro Oxidative Metabolism of Finasteride PubMed · 1995
    3. In Vitro Biotransformation of Finasteride in Rat Hepatic Microsomes: Isolation and Characterization of Metabolites PubMed · 1994
    4. Finasteride: A Slow-Binding 5-Alpha-Reductase Inhibitor Biochemistry · 1993
    5. Disposition and Pharmacokinetics of [14C]Finasteride After Oral Administration in Humans PubMed · 1992