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This report describes a patient with biotinidase deficiency presenting bilateral optic atrophy, and confirms autosomal recessive inheritance through enzyme dosage analysis in the patient and family members.

In this study, itraconazole was shown to accumulate in the deeper skin layers of guinea pigs after oral administration, suggesting this delivery method effectively targets infective organisms there.

In this study, plucked rat hair showed greater accumulation of injected radioisotopes than shaved hair, which may have implications for measuring exposure and understanding follicle tissue processes.

This review discusses biotin and biotinidase deficiencies, their symptoms, and methods of medical management, without presenting new clinical findings.

This study observed that the toxicity of Doxil in metastatic breast carcinoma patients is both dose and schedule dependent, with clear correlations to pharmacokinetic parameters.

This study demonstrates that bioequivalence for proposed 50-mg ritlecitinib capsules versus clinical 100-mg capsules can be supported using a PBPK model-based biowaiver, achieving over 90% probability of success.

This study demonstrated radiocalcium uptake in skin, eye, cartilage, and mucous glands, with the highest concentration in the hair follicle's keratogenous zone.

This review discusses various methods to assess bioequivalence between dermatologic drugs and highlights the potential of visual inspection and percutaneous penetration research.

This article discusses the preparation of tritium-labeled testosterone metabolites and reports no new experimental findings.

This study examined the pharmacokinetics of finasteride in pigs and found that ketoconazole coadministration affected its distribution across various plasma compartments, bile, and urine.

This study demonstrated that metabolomics could identify persistent biomarkers distinguishing between heavy ion and γ radiation exposures, offering a potential tool for assessing long-term radiation risk for intestinal pathologies.

This review examines the main absorption sites and influencing factors for orally administered drugs, highlighting variables such as solubility and gastrointestinal conditions that affect drug absorption in the small intestine and the development of effective drug delivery systems.

This bibliometric review analyzes trends in published research on ocean pollution biodegradation and bioremediation over time, reporting a notable growth in related publications from 2010 to 2022.

This review discusses biotinidase deficiency, noting that biotin treatment from birth can prevent symptoms, but acknowledges the complexity and need for further understanding due to late-onset cases with varied clinical findings.

This study found that early biochemical screening and molecular confirmation are crucial for distinguishing profound from partial biotinidase deficiency, which supports timely treatment and management in symptomatic children.

This study found that the metabolic profile of finasteride in pigs closely matches that of humans, supporting the use of pigs for studying human drug metabolism.

QMSI effectively maps and quantifies drug distribution in skin tissues.

This study found that after topical application in rats, 1,24-dihydroxyvitamin D3 absorbed through both the stratum corneum and hair follicles, with about 30% excreted via the faeces.

In this study, the researchers compared the pharmacokinetics and tissue distribution of dihydroartemisinin in nanostructured lipid carriers versus in solution, finding longer mean residence times and variable organ accumulation with the nanostructured lipid carriers.

In this case study, biotin supplementation was reported to interfere with free testosterone assay results, leading to falsely low readings in a postmenopausal woman with hyperandrogenism.

This study found that the metabolism of finasteride in rat hepatic microsomes involves key hydroxylation steps, highlighting the role of a novel enzyme in 6 alpha-hydroxylation.

This study found that 86% of patients with follicular non-Hodgkin's lymphoma were alive and nearly two-thirds remained in complete remission eight years after initial treatment with the radioimmunotherapy drug Bexxar.

In this study, penetration of FA-PLGA nanoparticles into hair follicles was observed in excised dog, rat, and porcine skin, with the deepest penetration in porcine skin, suggesting its similarity to human skin for drug delivery studies.

This article discusses the BIOMAP consortium's efforts in standardizing data for atopic dermatitis and psoriasis research to facilitate personalized medicine, but it presents no new research findings.

This review discusses the role of biotin in metabolism and its dietary requirements, but provides no new experimental findings.

This review highlights the potential analytic interference of high-dose biotin with immunochemical tests, which may lead to diagnostic errors and suggests pausing biotin consumption before laboratory testing.

This review discusses the role of biotin in metabolism and the consequences of its deficiency, reporting no new clinical results.

This article reviews the potential of using PBM in 3D tissue engineering to improve cell viability under stress conditions but reports no new experimental findings.

Finasteride and dutasteride's effects are mainly due to target binding saturation and slow enzyme turnover.