TLDR Oral itraconazole effectively reaches and treats deep skin layers in guinea pigs.
The study investigated the distribution of orally administered 3H-labeled itraconazole in guinea pigs. After dosing the animals with 10 mg/kg/day for 2 days, autoradiography revealed that itraconazole accumulated in the epidermis, hair follicles, sebaceous glands, dermal fat, and hypodermal muscle tissue at 6, 24, and 48 hours post-administration. However, by 96, 168, and 336 hours, the drug's presence decreased to background levels. These findings supported the effectiveness of oral itraconazole in targeting deeper skin layers to eradicate infective organisms.
October 2018 in “Springer eBooks” The document concludes that various hair disorders have different treatments, including medication, surgery, and addressing underlying causes.
30 citations,
April 2018 in “Experimental Dermatology” The article concludes that developing in vitro models for human hair structures is important for research and reducing animal testing, but there are challenges like obtaining suitable samples and the models' limitations.
April 2017 in “Journal of Dermatological Science” Certain flavonoids can improve the growth of pigmented hair in mice.
41 citations,
June 2013 in “PLOS ONE” Engineered skin substitutes can grow hair but have limitations like missing sebaceous glands and hair not breaking through the skin naturally.
85 citations,
July 2012 in “Cold Spring Harbor perspectives in biology” The skin protects the body and is constantly renewed by stem cells; disruptions can lead to cancer.
