Biotin: Essential Vitamin for Lipid Metabolism and Cellular Functions

    February 1994 in “ Neuroscience letters ”
    TLDR People need different amounts of biotin based on age and it's important for health, with many foods providing enough.
    Biotin, a water-soluble vitamin crucial for lipid metabolism, amino acid breakdown, and other cellular functions, has recommended daily intakes of 0.7 μg/kg for infants, 8–20 μg/day for children depending on age, 30 μg/day for adults, and 35 μg/day during lactation. Intestinal bacteria typically provide sufficient biotin, with foods like soybeans, liver, cauliflower, mushrooms, bean sprouts, and eggs being significant sources. Deficiency in biotin can lead to a range of health issues, including impaired glucose tolerance, mental dysfunction, muscle pain, sensory disturbances, appetite loss, dermatitis, hair loss, and weakened immune response. Biotin absorption in the intestine is facilitated by a sodium/multivitamin cotransporter and regulated by protein kinase C and calcium/calmodulin signaling, ensuring adaptation to varying intake levels.
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