Time-Dependent 53BP1 Foci Kinetics in X-Irradiated Human Hair Follicle Dermal Papilla Cells

    January 2026 in “ Journal of Radiation Research ”
    Daisuke Hanamiya, Reo Etani, Mitsuaki Ojima
    Studysummary This study found that using human hair follicle dermal papilla cells, 53BP1 focus counting can estimate radiation doses from 50 mGy after 5 hours, and focus size analysis refines dose estimation for doses ≥ 500 mGy up to 96 hours.
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    Research cited in this study 3

    1. Cyclical Dermal Micro-Niche Switching Governs the Morphological Infradian Rhythm of Mouse Zigzag Hair Nature Communications · 2023
    2. Microenvironmental Reprogramming by Three-Dimensional Culture Enables Dermal Papilla Cells to Induce De Novo Human Hair-Follicle Growth Proceedings of the National Academy of Sciences of the United States of America · 2013
    3. Human Follicular Stem Cells: Their Presence in Plucked Hair and Follicular Cell Culture British Journal of Dermatology · 2004