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Super-enhancers controlled by pioneer factors like SOX9 are crucial for stem cell adaptability and identity.

The conclusion is that understanding how hair follicle stem cells live or die is important for maintaining healthy tissue and repairing injuries, and could help treat hair loss, but there are still challenges to overcome.

Increased ODC activity leads to skin tumors by recruiting stem cells, not by toxic byproducts.

GDNF helps grow hair and heal skin wounds by acting on hair stem cells.

The skin protects the body and is constantly renewed by stem cells; disruptions can lead to cancer.

Different human hair follicle stem cells grow at different rates and respond differently to a baldness-related compound.

Two-photon microscopy effectively tracks live stem cell activity in mouse skin with minimal harm and clear images.

YAP and TAZ proteins are necessary for the development of two types of skin cancer.

The gene Msx2 is crucial for hair follicle regeneration during wound healing.

The TGF-β family helps control how cells change and move, affecting skin, hair, and organ development.

Fibroblasts, cells usually linked to tissue repair, also help regenerate various organs and their ability decreases with age. Turning adult fibroblasts back to a younger state could be a new treatment approach.

Wounds can regenerate hair in young mice, but this ability declines with age, offering insights for improving tissue regeneration in the elderly.

MOF controls key genes for skin development by regulating mitochondrial and ciliary functions.

The nervous system helps control stem cell behavior and immune responses, affecting tissue repair and maintenance.

Understanding gene expression in hair follicles can reveal insights into hair growth and disorders.

Hair growth phase and certain genes can speed up wound healing, while an inflammatory mediator can slow down new hair growth after a wound. Understanding these factors can improve tissue regeneration during wound healing.

Wnt signaling is crucial for skin wound healing and reducing scars.

New treatments for hair loss, fertility, and wound healing are being explored.

The skin's internal clock affects healing, cancer risk, aging, immunity, and hair growth, and disruptions can harm skin health.

α3β1-integrin is crucial for maintaining normal hair follicle shape and function but not needed for the development of the surrounding skin.

Improved understanding of stem cell mechanisms can enhance skin tissue engineering.

Scientists have improved 3D models of human skin for research and medical uses, but still face challenges in perfectly replicating real skin.

The CUBIC protocol allows detailed 3D visualization of proteins in mouse skin biopsies.

The "Punch Assay" can regenerate hair follicles efficiently in mice and has potential for human hair regeneration.

Hair follicles in the back of the rosette fancy mouse have reversed orientations due to a gene mutation.

Mechanical forces are crucial for shaping cells and forming tissues during development.

Deleting the PTEN gene in mice causes nerve cells to grow larger and heal better after injury, but may cause overgrowth and hair loss in older mice.

The skin and thymus develop similarly to protect and support immunity.

The Wnt/β-catenin pathway helps tissue regeneration but can also cause fibrosis, and drugs that inhibit this pathway may aid in healing skin and heart tissues.

MicroRNAs are crucial for controlling skin development and healing by regulating genes.